Klaff L J, Vinik A I, Berelowitz M, Jackson W P
S Afr Med J. 1978 Jul 22;54(4):149-53.
Conventional insulins contain impurities which are immunogenic; these include pancreatic polypeptide (PP), glucagon and somatostatin and intermediates of insulin synthesis co-extracted during purification. Monocomponent (MC) insulins are free of these contaminants. In 49 insulin-treated diabetic patients, antibodies were found to insulin (94%), pro-insulin (68%) and PP (68%). Antibodies to glucagon and somatostatin were not detected. There was a significantly lower mean maximum binding and titre of insulin and PP antibodies and total circulating insulin (i.e. antibody bound and free) in patients receiving MC insulin. In patients treated with MC insulins for longer than 2 years there was a significant fall in the mean maximum binding of insulin and total serum insulin, but no consistent change in diabetes control and daily insulin dose. It seems that except in the special instances of fat atrophy, insulin allergy and certain cases of insulin resistance, there is no need to resort to MC insulin.
常规胰岛素含有具有免疫原性的杂质；这些杂质包括胰多肽（PP）、胰高血糖素、生长抑素以及纯化过程中共同提取的胰岛素合成中间体。单组分（MC）胰岛素不含这些污染物。在49例接受胰岛素治疗的糖尿病患者中，发现了针对胰岛素（94%）、胰岛素原（68%）和PP（68%）的抗体。未检测到针对胰高血糖素和生长抑素的抗体。接受MC胰岛素治疗的患者中，胰岛素和PP抗体以及总循环胰岛素（即抗体结合的和游离的）的平均最大结合力和滴度显著降低。接受MC胰岛素治疗超过2年的患者，胰岛素的平均最大结合力和总血清胰岛素显著下降，但糖尿病控制情况和每日胰岛素剂量没有持续变化。似乎除了脂肪萎缩、胰岛素过敏和某些胰岛素抵抗的特殊情况外，没有必要使用MC胰岛素。
