Craig S P, Buckle V J, Lamouroux A, Mallet J, Craig I
Cytogenet Cell Genet. 1986;42(1-2):29-32. doi: 10.1159/000132246.
Phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH) are consecutive enzymes in the metabolic pathway leading to the production of catecholamine neurotransmitters. A comparison of recently available sequence data of these enzymes in the rat indicates about 70% homology in the 3' coding regions. We have localized TH by in situ hybridization to human chromosome region 11p15. Consideration of this assignment and that of PAH to chromosome 12, together with the known distribution of other pairs of related genes on these two chromosomes, provides convincing evidence of their ancestral relationship and suggests a role for gene duplication in the diversification of metabolic pathways in the vertebrate ancestors of mammals.
苯丙氨酸羟化酶（PAH）和酪氨酸羟化酶（TH）是导致儿茶酚胺神经递质产生的代谢途径中的连续酶。最近获得的大鼠中这些酶的序列数据比较表明，其3'编码区约有70%的同源性。我们通过原位杂交将TH定位到人类染色体区域11p15。考虑到这一定位以及PAH定位于12号染色体，再结合这两条染色体上其他相关基因对的已知分布情况，为它们的祖先关系提供了令人信服的证据，并表明基因复制在哺乳动物脊椎动物祖先代谢途径多样化中发挥了作用。
