Griffiths B, Matthews D J, West L, Attwood J, Povey S, Swallow D M, Gum J R, Kim Y S
MRC Human Biochemical Genetics Unit, University College London.
Ann Hum Genet. 1990 Oct;54(4):277-85. doi: 10.1111/j.1469-1809.1990.tb00383.x.
A cDNA coding for a mucin expressed in intestine has recently been cloned (Gum et al. 1989). We describe here the use of this cDNA to map the gene (MUC2) to human chromosome 11 using somatic cell hybrids, and to make the regional localization to 11p15 by in situ hybridization. Analysis of the CEPH (Centre d'Etude du Polymorphisme Humain) families revealed that MUC2 forms part of the tight linkage group on 11p15 which contains HRAS, INS, TH and HBBC.
最近已克隆出一个编码在肠道中表达的粘蛋白的cDNA（古姆等人，1989年）。我们在此描述使用该cDNA通过体细胞杂种将基因（MUC2）定位到人类11号染色体，并通过原位杂交将其区域定位到11p15。对CEPH（人类多态性研究中心）家族的分析表明，MUC2是11p15上紧密连锁群的一部分，该连锁群包含HRAS、INS、TH和HBBC。
