Feng Qing-Yang, Hu Zi-Xuan, Song Xi-Ling, Pan Hong-Wei
Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China.
Department of Public Health and Preventive Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Int J Ophthalmol. 2017 Jun 18;10(6):973-981. doi: 10.18240/ijo.2017.06.22. eCollection 2017.
Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of metalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. We illustrate their possible mechanisms in the pathogenesis of pterygium as well as the related intervention based on them for pterygium therapy.
翼状胬肉是一种由多种因素引起的常见眼表疾病。翼状胬肉的确切发病机制尚不清楚。在翼状胬肉中发现了许多基因和蛋白质，它们在该疾病的发生和发展中发挥着不同的作用。我们检索了Web of Science和PubMed有史以来关于该主题的文献。我们使用的关键词包括翼状胬肉、基因、蛋白质、血管生成、纤维化、增殖、炎症、发病机制和治疗。在这篇综述中，我们总结了与正常结膜或角膜相比，翼状胬肉中一系列基因和蛋白质的异常表达，包括生长因子、基质金属蛋白酶和金属蛋白酶组织抑制剂、白细胞介素、肿瘤抑制基因、增殖相关蛋白、凋亡相关蛋白、细胞粘附分子、细胞外基质蛋白、热休克蛋白和紧密连接蛋白。我们阐述了它们在翼状胬肉发病机制中的可能作用机制以及基于它们的翼状胬肉治疗相关干预措施。
