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染色体重排对白血病DNA甲基化模式的影响。

Impact of Chromosomal Rearrangement upon DNA Methylation Patterns in Leukemia.

作者信息

Byun Hyang-Min, Eshaghian Shahrooz, Douer Dan, Trent Jonathen, Garcia-Manero Guillermo, Bhatia Ravi, Siegmund Kim, Yang Allen S

机构信息

Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE4 5PLUnited Kingdom.

Jane Anne Nohl Division of Hematology; University of Southern California, Los Angeles, CA, USA.

出版信息

Open Med (Wars). 2017 May 4;12:76-85. doi: 10.1515/med-2017-0014. eCollection 2017.

DOI:10.1515/med-2017-0014
PMID:28730166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5444343/
Abstract

Genomic instability, including genetic mutations and chromosomal rearrangements, can lead to cancer development. Aberrant DNA methylation occurs commonly in cancer cells. The aim of this study is to determine the effects of a specific chromosomal lesion the translocation t(9:22), in establishing DNA methylation profiles in cancer. We compared DNA methylation of 1,505 selected promoter CpGs in chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL) with and without the Philadelphia chromosome t(9:22), CD34+ hematopoietic stem cells transfected with , and other tumors without (acute promyelocytic leukemia (APL) and gastrointestinal stromal tumors (GIST). In this study, the DNA methylation profile of CML was more closely related to APL, another myeloid leukemia, than Ph+ ALL. Although DNA methylation profiles were consistent within a specific tumor type, overall DNA methylation profiles were no influenced by gene translocation in the cancers and tissues studied. We conclude that DNA methylation profiles may reflect the cell of origin in cancers rather than the chromosomal lesions involved in leukemogenesis.

摘要

基因组不稳定，包括基因突变和染色体重排，可导致癌症发生。异常的DNA甲基化在癌细胞中普遍存在。本研究的目的是确定一种特定的染色体病变——易位t(9:22)，在建立癌症DNA甲基化图谱中的作用。我们比较了慢性粒细胞白血病（CML）、有或无费城染色体t(9:22)的急性淋巴细胞白血病（ALL）、转染了的CD34+造血干细胞以及其他无该染色体病变的肿瘤（急性早幼粒细胞白血病（APL）和胃肠道间质瘤（GIST））中1505个选定启动子CpG的DNA甲基化情况。在本研究中，CML的DNA甲基化图谱与另一种髓系白血病APL的关系比与Ph+ ALL的关系更密切。尽管特定肿瘤类型内的DNA甲基化图谱是一致的，但在所研究的癌症和组织中，总体DNA甲基化图谱不受基因易位的影响。我们得出结论，DNA甲基化图谱可能反映癌症的起源细胞，而非白血病发生过程中涉及的染色体病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/828ef1ea88f1/med-12-076-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/92e0b5b8bbae/med-12-076-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/aa340523ffce/med-12-076-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/c435b0cfd597/med-12-076-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/72e333b0f0a4/med-12-076-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/9fd48a65fd63/med-12-076-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/828ef1ea88f1/med-12-076-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/92e0b5b8bbae/med-12-076-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/aa340523ffce/med-12-076-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/c435b0cfd597/med-12-076-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/72e333b0f0a4/med-12-076-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/9fd48a65fd63/med-12-076-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5444343/828ef1ea88f1/med-12-076-g006.jpg

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2
Dissecting the role of aberrant DNA methylation in human leukaemia.剖析异常DNA甲基化在人类白血病中的作用。
Nat Commun. 2015 May 22;6:7091. doi: 10.1038/ncomms8091.
3
TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.
TET2突变影响慢性粒单核细胞白血病中增强子和转录因子结合位点的非CpG岛DNA甲基化。
Cancer Res. 2015 Jul 15;75(14):2833-43. doi: 10.1158/0008-5472.CAN-14-0739. Epub 2015 May 13.
4
The limited contribution of DNA methylation to PML-RARα induced leukemia.DNA甲基化对早幼粒细胞白血病锌指蛋白-维甲酸受体α融合基因（PML-RARα）诱导白血病的作用有限。
Oncotarget. 2013 Jan;4(1):5-6. doi: 10.18632/oncotarget.875.
5
Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns.组织来源决定癌症相关的CpG岛启动子高甲基化模式。
Genome Biol. 2012 Oct 3;13(10):R84. doi: 10.1186/gb-2012-13-10-r84.
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