患有大动脉炎的男性同胞提示存在遗传病因。

Male siblings with Takayasu's arteritis suggest genetic etiology.

作者信息

Kodama K, Kida O, Morotomi Y, Tanaka K

出版信息

Heart Vessels. 1986;2(1):51-4. doi: 10.1007/BF02060246.

DOI:10.1007/BF02060246

Abstract

Takayasu's arteritis is a nonspecific arteritis involving the aorta and its major branches. The disease mainly affects young females and familial incidence is uncommon. In this paper, two rare cases of male siblings with Takayasu's arteritis and the results of their HLA typing are described. The HLA haplotype of the two cases was completely identical--A2-B40-Cwl and A24(9)-Bw59-Cwl, DR2, and DR4. It is reported that Bw52(5) is strongly associated with the disease. However, in our cases, Bw52(5) was not found, while DR2 and DR4, which have been reported in association with several autoimmune disease, were detected. Accordingly, in these cases, genetic factors might be associated with the pathogenesis of the disease through an autoimmune mechanism.

摘要

高安动脉炎是一种累及主动脉及其主要分支的非特异性动脉炎。该疾病主要影响年轻女性，家族发病率并不常见。本文描述了两例患有高安动脉炎的男性同胞的罕见病例及其HLA分型结果。这两例病例的HLA单倍型完全相同——A2 - B40 - Cwl和A24(9) - Bw59 - Cwl、DR2和DR4。据报道，Bw52(5)与该疾病密切相关。然而，在我们的病例中未发现Bw52(5)，而检测到了与几种自身免疫性疾病相关的DR2和DR4。因此，在这些病例中，遗传因素可能通过自身免疫机制与该疾病的发病机制相关。