cystobactamids 的全合成及 cystobactamid 919-2 的结构确证
Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2.
机构信息
Department of Chemistry, University of Munich, Butenandtstrasse 5-13, Haus F, 81377, Munich, Germany.
Department of Chemistry, New York University, 100 Washington Square East, Room 712, New York, NY, 10003, USA.
出版信息
Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12755-12759. doi: 10.1002/anie.201705387. Epub 2017 Aug 30.
The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram-positive and Gram-negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919-2 from three fragments. Our convergent synthesis enabled both the confirmation of the correct structure and the determination of the absolute configuration of cystobactamid 919-2.
胱抑素类是具有空前化学支架的一类具有抗菌活性的天然产物，对革兰氏阳性和革兰氏阴性病原体均有活性。本文首次从三个片段全合成胱抑素 919-2。我们的收敛性合成不仅证实了胱抑素 919-2 的正确结构，而且确定了其绝对构型。
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