Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, E-07122 Palma de Mallorca, Balearic Islands, Spain.
Nutrition and Dietetics Department, School of Pharmacy, University of Concepción, 4070386 Concepción, VIII - Bio Bio Region, Chile.
Eur J Med Chem. 2018 Jun 10;153:123-130. doi: 10.1016/j.ejmech.2017.07.018. Epub 2017 Jul 13.
Cardiovascular disease (CVD) represents a global burden with a prevalence that continues increasing progressively. CVD comprises a group of disorders of the heart and blood vessels including coronary heart disease, cerebrovascular disease and peripheral arterial disease. This group of disorders is associated with an inflammatory process which can participate in the pathophysiology of these diseases. Inflammation resolution is an active process involving the participation of pro-resolving mediators such as lipoxins, resolvins, protectins and maresins. Pro-resolving mediators are bioactive molecules generated from omega-3 polyunsaturated fatty acids (PUFAs); among these eicosapentaenoic acid (EPA; C20:5n3) and docosahexaenoic acid (DHA; C22:6n3) are the precursors of resolvins. Pro-resolving mediators orchestrate the correct resolution of inflammation and also stimulate tissue regeneration. Their deregulation can lead to chronic inflammation involving CVD. The discovery of these novel lipid mediators opens a new range of possibilities for the design of anti-inflammatory agents with therapeutic potential for a wide variety of diseases. The present work summarizes the available data about the general characteristics, structure and biosynthesis of resolvins and their relation as protective compounds in CVD.
心血管疾病（CVD）是一种全球性疾病，其患病率呈持续上升趋势。CVD 包括一组与心脏和血管有关的疾病，包括冠心病、脑血管病和外周动脉疾病。这组疾病与炎症过程有关，炎症过程可能参与这些疾病的病理生理学。炎症解决是一个涉及参与促解决介质（如脂氧素、 resolvins、保护素和maresins）的主动过程。促解决介质是由ω-3 多不饱和脂肪酸（PUFA）生成的生物活性分子；其中二十碳五烯酸（EPA；C20:5n3）和二十二碳六烯酸（DHA；C22:6n3）是 resolvins 的前体。促解决介质协调炎症的正确解决，同时刺激组织再生。它们的失调可能导致涉及 CVD 的慢性炎症。这些新型脂质介质的发现为设计具有治疗多种疾病潜力的抗炎药物开辟了新的可能性。本工作总结了关于 resolvins 的一般特征、结构和生物合成及其在 CVD 中作为保护化合物的关系的现有数据。
