Knutsson A, Akerstedt T, Jonsson B G, Orth-Gomer K
Lancet. 1986 Jul 12;2(8498):89-92. doi: 10.1016/s0140-6736(86)91619-3.
504 papermill workers were followed up for 15 years and the incidence of ischaemic heart disease (IHD) in shift workers was compared with that in day workers. The relative risk (RR) of IHD rose with increasing duration of reported exposure to shift work. A significant risk of IHD was associated with an exposure of 11 - 15 years (RR = 2.2, p less than 0.04) and of 16 to 20 years (RR = 2.8, p less than 0.03. The association was independent of age and smoking history. The RR of IHD fell sharply after 20 years of shift work. This was ascribed to the pronounced positive selection that had taken place in this group.
对504名造纸厂工人进行了15年的随访，并比较了轮班工人与日班工人的缺血性心脏病（IHD）发病率。IHD的相对风险（RR）随着报告的轮班工作暴露时间的增加而上升。IHD的显著风险与11至15年的暴露时间相关（RR = 2.2，p < 0.04）以及16至20年的暴露时间相关（RR = 2.8，p < 0.03）。这种关联独立于年龄和吸烟史。轮班工作20年后，IHD的RR急剧下降。这归因于该组中发生的明显的正向选择。
