Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Trends Biotechnol. 2017 Nov;35(11):1074-1087. doi: 10.1016/j.tibtech.2017.06.015. Epub 2017 Jul 19.
Over the last decade, numerous investigations have attempted to clarify the intricacies of tumor development to propose effective approaches for cancer treatment. Thanks to the unique properties of hydrogels, researchers have made significant progress in tumor model reconstruction, tumor diagnosis, and associated therapies. Notably, hydrogel-based systems can be adjusted to respond to cancer-specific hallmarks and/or external stimuli. These well-known drug reservoirs can be used as smart carriers for multiple cargos, including both naked and nanoparticle-encapsulated chemotherapeutics, genes, and radioisotopes. Recent works have attempted to specialize hydrogels for cancer research; we comprehensively review this topic for the first time, synthesizing past results and defining paths for future work.
在过去的十年中，许多研究试图阐明肿瘤发展的复杂性，以提出癌症治疗的有效方法。得益于水凝胶的独特性质，研究人员在肿瘤模型重建、肿瘤诊断和相关治疗方面取得了重大进展。值得注意的是，水凝胶基系统可以进行调整以响应癌症特异性特征和/或外部刺激。这些众所周知的药物储库可用作多种载药的智能载体，包括裸药和纳米颗粒包封的化疗药物、基因和放射性同位素。最近的工作尝试将水凝胶专门用于癌症研究；我们首次全面回顾了这个主题，综合了过去的结果并为未来的工作定义了方向。
