School of Semiconductor and Chemical Engineering, Nanomaterials Processing Research Center, Chonbuk National University, 567 Baekjedaero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
School of Semiconductor and Chemical Engineering, Nanomaterials Processing Research Center, Chonbuk National University, 567 Baekjedaero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
J Colloid Interface Sci. 2017 Nov 15;506:188-196. doi: 10.1016/j.jcis.2017.07.037. Epub 2017 Jul 14.
Printable electronics is a subject of great interest for low-cost, facile and environmentally-friendly large scale device production. But, it still remains challenging for printable biosensor development. Herein, we present the fabrication of nozzle-jet printed flexible field-effect transistor (FET) glucose biosensor. The silver source-drain electrodes and ZnO seed layers were printed on flexible substrate by nozzle-jet printer followed by ZnO nanorods (ZnO NRs) synthesis and glucose oxidase (GOx) immobilization. Utilization of nozzle-jet printing methods resulted in highly reproducible electrodes with well-defined vertical grown ZnO NRs for high GOx loading and enhanced glucose sensing performance in a wide glucose detection range. The stability, anti-interference ability, reproducibility, reusability, and applicability in human serum samples were also assessed. Overall, biosensor fabrication using nozzle-jet printer will not only provide large scale production of highly reproducible electrodes but also reduce the fabrication cost. Additionally, printed electrodes can be modified accordingly for different analyte detection.
打印电子学是低成本、简便和环保的大规模器件生产的研究热点。但是，对于可打印生物传感器的发展仍然具有挑战性。在此，我们介绍了喷墨打印柔性场效应晶体管（FET）葡萄糖生物传感器的制作。通过喷墨打印机将银源漏电极和 ZnO 种子层打印在柔性基底上，然后合成 ZnO 纳米棒（ZnO NRs）并固定葡萄糖氧化酶（GOx）。喷墨打印方法的使用导致具有高度重现性的电极，具有定义明确的垂直生长的 ZnO NRs，可实现高 GOx 负载，并在宽葡萄糖检测范围内增强葡萄糖传感性能。还评估了传感器的稳定性、抗干扰能力、重现性、可重复性以及在人血清样本中的适用性。总体而言，使用喷墨打印机进行生物传感器的制作不仅可以提供大规模生产高度重现性电极，还可以降低制造成本。此外，可以相应地修饰打印电极以用于不同分析物的检测。
