Dunnett S B, Whishaw I Q, Jones G H, Isacson O
Neurosci Lett. 1986 Jul 11;68(1):127-33. doi: 10.1016/0304-3940(86)90242-9.
To assess the capacity of dopamine-rich grafts to ameliorate conditioned behavioural deficits induced by dopamine depleting lesions, rats with unilateral 6-hydroxydopamine lesions and intrastriatal grafts were compared with rats with lesions alone and with unoperated control rats in learning a conditioned turning response ('conditioned rotation') for water. The lesions impaired conditioned contralateral rotation and the grafts ameliorated the impairment. By contrast, the grafts introduced an ipsilateral impairment which was not apparent in the rats with lesions alone. The results show that some aspects of graft function are adaptive, but that other aspects of function are not well controlled by the host brain, and so may be maladaptive.
为评估富含多巴胺的移植物改善多巴胺耗竭性损伤所致条件性行为缺陷的能力，将单侧6-羟基多巴胺损伤并纹状体内植入移植物的大鼠与单纯损伤大鼠及未手术的对照大鼠进行比较，观察它们学习水的条件性转向反应（“条件性旋转”）的情况。损伤会损害条件性对侧旋转，而移植物可改善这种损伤。相比之下，移植物会引发同侧损伤，这在单纯损伤的大鼠中并不明显。结果表明，移植物功能的某些方面具有适应性，但功能的其他方面未得到宿主大脑的良好控制，因此可能具有 maladaptive（此词未准确对应中文，可根据上下文理解为“适应不良”之类意思）。
