Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Pediatr Nephrol. 2017 Dec;32(12):2293-2301. doi: 10.1007/s00467-017-3750-0. Epub 2017 Jul 22.
Little is known about the associations between allergic disease, sleep-disordered breathing (SDB), and childhood nocturnal enuresis (NE). We examined whether allergic disease and SDB were associated with childhood NE.
Data were assessed from the 2007-2012 Taiwan National Health Insurance Research Database. We enrolled 4308 children aged 5-18 years having NE diagnosis and age- and sex-matched 4308 children as the control group. The odds ratios of NE were calculated to determine an association with preexisting allergic disease and SDB.
A total of 8616 children were included in the analysis. Prevalence of allergic diseases and SDB was significantly higher for the NE group than the control group (all p < 0.001). After adjusting odds ratios for potential confounding factors, except asthma, children with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and obstructive sleep apnea (OSA) had significantly higher odds of NE compared with children never diagnosed. With stratification for sex, girls with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, OSA, and snoring had significantly higher odds of NE, compared with girls never diagnosed. Only boys with allergic rhinitis and OSA were associated with increased odds of NE. With stratification for age, children aged 5-12 years with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and OSA had significantly higher odds of NE compared with those never diagnosed. Odds of NE increased with the number of comorbid allergic diseases.
Allergic diseases and SDB are associated with increased odds of childhood NE. The odds of NE increased with the number of comorbid allergic diseases present.
目前对于过敏疾病、睡眠呼吸障碍（SDB）与儿童夜间遗尿症（NE）之间的关系知之甚少。我们研究了过敏疾病和 SDB 是否与儿童夜间遗尿症有关。
数据来自于 2007-2012 年台湾全民健康保险研究数据库。我们纳入了 4308 例年龄为 5-18 岁且有夜间遗尿症诊断的儿童，按照年龄和性别匹配了 4308 例作为对照组。计算了夜间遗尿症的比值比以确定与先前存在的过敏疾病和睡眠呼吸障碍的关系。
共纳入了 8616 例儿童。与对照组相比，夜间遗尿症组的过敏疾病和睡眠呼吸障碍发生率明显更高（均 p<0.001）。在调整了潜在混杂因素的比值比后，除哮喘外，患有过敏性鼻炎、特应性皮炎、过敏性结膜炎和阻塞性睡眠呼吸暂停（OSA）的儿童发生夜间遗尿症的可能性明显高于从未被诊断的儿童。按性别分层，患有过敏性鼻炎、特应性皮炎、过敏性结膜炎、OSA 和打鼾的女孩发生夜间遗尿症的可能性明显高于从未被诊断的女孩。仅患有过敏性鼻炎和 OSA 的男孩与夜间遗尿症的发生风险增加有关。按年龄分层，5-12 岁患有过敏性鼻炎、特应性皮炎、过敏性结膜炎和 OSA 的儿童发生夜间遗尿症的可能性明显高于从未被诊断的儿童。夜间遗尿症的发生风险随合并过敏疾病数量的增加而增加。
过敏疾病和 SDB 与儿童夜间遗尿症的发生风险增加有关。夜间遗尿症的发生风险随合并过敏疾病数量的增加而增加。
