Yang Ting, Wang Han-Rui, Mou Ya-Kui, Liu Wan-Chen, Wang Yao, Song Xiao-Yu, Ren Chao, Song Xi-Cheng
Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, People's Republic of China.
Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai Yuhuangding Hospital, Yantai, People's Republic of China.
Nat Sci Sleep. 2024 Sep 19;16:1451-1467. doi: 10.2147/NSS.S482258. eCollection 2024.
Patients with allergic rhinitis (AR) have a high incidence of sleep disorders, such as insomnia, which can easily exacerbate nasal symptoms. The aggravation of nasal symptoms further promotes the deterioration of sleep disorders, forming a vicious cycle. Severe cases may even trigger psychological and neurological issues, such as anxiety, depression, and cognitive impairment, causing significant distress to patients, making clinical diagnosis and treatment difficult, and increasing costs. Furthermore, satisfactory therapeutics remain lacking. As the pathogenesis of AR-associated sleep disorders is not clear and research is still insufficient, paying attention to and understanding AR-related sleep disorders is crucial in clinical practice. Multiple studies have shown that the most crucial issues in current research on AR and sleep are analyzing the relationship between AR and sleep disorders, searching for the influencing factors, and investigating potential targets for diagnosis and treatment. This review aimed to identify and summarize the results of relevant studies using "AR" and "sleep disorders" as search terms. In addition, we evaluated the correlation between AR and sleep disorders and examined their interaction and potential mechanisms, offering a foundation for additional screening of potential diagnostic biomarkers and therapeutic targets.
过敏性鼻炎（AR）患者睡眠障碍的发生率很高，如失眠，这很容易加重鼻部症状。鼻部症状的加重进一步促使睡眠障碍恶化，形成恶性循环。严重的病例甚至可能引发心理和神经问题，如焦虑、抑郁和认知障碍，给患者带来极大痛苦，使临床诊断和治疗变得困难，并增加成本。此外，目前仍缺乏令人满意的治疗方法。由于AR相关睡眠障碍的发病机制尚不清楚且研究仍不充分，在临床实践中关注和了解AR相关睡眠障碍至关重要。多项研究表明，当前AR与睡眠研究中最关键的问题是分析AR与睡眠障碍之间的关系、寻找影响因素以及探究潜在的诊断和治疗靶点。本综述旨在识别和总结以“AR”和“睡眠障碍”为检索词的相关研究结果。此外，我们评估了AR与睡眠障碍之间的相关性，研究了它们的相互作用和潜在机制，为进一步筛选潜在的诊断生物标志物和治疗靶点提供依据。
