Fritze J, Schneider B, Maurer K
Department of Psychiatry, University of Frankfurt/Main, Federal Republic of Germany.
J Neural Transm (Vienna). 1996;103(10):1221-9. doi: 10.1007/BF01271207.
Life-event research as well as neurobiological findings point to the relevance of adverse stress for the pathogenesis of affective disorders. The well established genetic root might be related to the sensitivity to stress. In concordance, recent studies showed a synergistic interaction between genetic loading and life-events concerning the precipitation of depression, i.e. there might exist a genetic sensitization to the adverse effects of stressors. The present investigation, using information extracted from 877 case records, did not reveal a synergistic interaction concerning the age at onset and the mean frequency and duration of episodes.
生活事件研究以及神经生物学研究结果表明，不良应激与情感障碍的发病机制相关。已确定的遗传根源可能与对压力的敏感性有关。与此一致的是，最近的研究表明，在抑郁症的发作方面，基因负荷与生活事件之间存在协同相互作用，即可能存在对应激源不良影响的遗传易感性。本研究利用从877例病例记录中提取的信息，未发现发病年龄与发作的平均频率和持续时间之间存在协同相互作用。
