Frey H H
Pharmacology. 1986;32(6):335-9. doi: 10.1159/000138189.
The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvulsant effect of the drugs was lost with higher doses which partly induced spontaneous convulsions. The comparatively high potency of pethidine in this model may point to a role of other receptors (or processes) besides the mu-receptor for this drug.
研究了吗啡、芬太尼、哌替啶和喷他佐辛对沙鼠抗空气冲击波诱发癫痫发作的作用。吗啡（皮下注射半数有效量=4.0毫克/千克）、芬太尼（皮下注射半数有效量=64微克/千克）和哌替啶（皮下注射半数有效量=2.4毫克/千克）可抑制严重的全身性癫痫发作，但喷他佐辛无此作用。高剂量用药时抗惊厥作用消失，且部分会诱发自发性惊厥。在该模型中哌替啶相对较高的效力可能表明，除μ受体外，该药物还有其他受体（或过程）起作用。
