Czuczwar S J, Frey H H
Neuropharmacology. 1986 May;25(5):465-9. doi: 10.1016/0028-3908(86)90169-3.
In mice, the influence of small (analgesic range) doses of morphine, fentanyl, meperidine and pentazocine on the thresholds for seizures induced by electroshock and pentetrazole was studied. The antinociceptive ED50 was determined against writhing induced by acetic acid or morphine (0.43 mg/kg, s.c.), fentanyl (0.018 mg/kg, s.c.), meperidine (2.6 mg/kg, s.c.), and pentazocine (2.0 mg/kg, s.c.). The electroconvulsive threshold was significantly elevated at doses slightly greater than (fentanyl and meperidine) or about twice the antinociceptive ED50 (morphine and pentazocine). Naloxone antagonized this effect in the case of morphine and fentanyl, but not in the case of meperidine and pentazocine. The threshold for clonic convulsions induced by intravenous infusion of pentetrazole was not influenced by morphine, fentanyl and meperidine, in the dose range studied, but was slightly increased by the smaller doses (2 and 4 mg/kg) of pentazocine. The tonic phase of pentetrazole-induced convulsions was suppressed by the larger doses of fentanyl, meperidine and pentazocine, though smaller doses of pentazocine significantly reduced the threshold for the extensor phase.
在小鼠中，研究了小剂量（镇痛范围）的吗啡、芬太尼、哌替啶和喷他佐辛对电休克和戊四氮诱发惊厥阈值的影响。测定了针对乙酸或吗啡（0.43毫克/千克，皮下注射）、芬太尼（0.018毫克/千克，皮下注射）、哌替啶（2.6毫克/千克，皮下注射）和喷他佐辛（2.0毫克/千克，皮下注射）诱发的扭体反应的抗伤害性ED50。在略高于（芬太尼和哌替啶）或约为抗伤害性ED50两倍（吗啡和喷他佐辛）的剂量下，电惊厥阈值显著升高。纳洛酮可拮抗吗啡和芬太尼的这种作用，但对哌替啶和喷他佐辛无效。在研究的剂量范围内，静脉注射戊四氮诱发的阵挛性惊厥阈值不受吗啡、芬太尼和哌替啶的影响，但较小剂量（2和4毫克/千克）的喷他佐辛可使其略有升高。较大剂量的芬太尼、哌替啶和喷他佐辛可抑制戊四氮诱发惊厥的强直期，不过较小剂量的喷他佐辛可显著降低伸肌期的阈值。
