Wang K, Wang Z, Si S, Liu X, Han Z, Tao J, Chen H, Suo C, Wei J, Tan R, Gu M
Department of Urology, First Affiliated Hospital With Nanjing Medical University, Nanjing, People's Republic of China.
Research Division of Clinical Pharmacology, First Affiliated Hospital With Nanjing Medical University, Nanjing, Research Division of Clinical Pharmacology, People's Republic of China.
Transplant Proc. 2017 Jul-Aug;49(6):1336-1343. doi: 10.1016/j.transproceed.2017.01.080.
Gingival overgrowth (GO) induced by cyclosporine (CsA), one of the common complications after kidney transplantation, is associated with a genetic component. However, the effect of TGF-β1 and MDR1 gene polymorphisms on the pathogenesis of CsA-induced GO remains to be determined. This study aimed to determine the association between TGF-β1 and MDR1 gene polymorphisms and CsA-induced GO in kidney transplant recipients.
The Pubmed, Embase, Cochrane Library, and Chinese CNKI (China National Knowledge Infrastructure) and Wanfang databases were comprehensively searched. Data were extracted and pooled results estimated from odds ratios (ORs) and 95% confidence intervals (CIs). In addition, quality assessment and publication bias of each eligible study were examined.
Three trials focusing on the relationship between TGF-β1 +869T>C and +915G>C and 3 studies on MDR1 C3435T gene polymorphisms and the onset of CsA-induced GO were included. No association between the +869T>C polymorphism and CsA-induced GO was found in the dominant model (TT+TC vs CC: OR, 0.77; 95% CI, 0.29-2.10; P = .614). In the recessive model, no association was found between the +915G>C polymorphism and CsA-induced GO (CC vs GG+GC: OR, 1.40; 95% CI, 0.81-2.43; P = .225). And in the dominant model, no significance was calculated between MDR1 C3435T gene polymorphisms and CsA-induced GO in kidney transplant recipients (TT vs CC+CT: OR, 1.14; 95% CI, 0.62-2.09; P = .68).
No significant association exists between TGF-β1 +869T>C, and +915G>C and MDR1 C3435T gene polymorphisms and the pathogenesis of CsA-induced GO in kidney transplant recipients.
环孢素（CsA）诱导的牙龈增生（GO）是肾移植术后常见并发症之一，与遗传因素有关。然而，转化生长因子-β1（TGF-β1）和多药耐药基因1（MDR1）基因多态性对CsA诱导的GO发病机制的影响尚待确定。本研究旨在确定TGF-β1和MDR1基因多态性与肾移植受者中CsA诱导的GO之间的关联。
全面检索了PubMed、Embase、Cochrane图书馆以及中国知网（CNKI）和万方数据库。提取数据并根据比值比（OR）和95%置信区间（CI）汇总估计结果。此外，对每项符合条件的研究进行质量评估和发表偏倚检查。
纳入了3项关注TGF-β1 +869T>C和+915G>C与CsA诱导的GO发病关系的试验，以及3项关于MDR1 C3435T基因多态性与CsA诱导的GO发病关系的研究。在显性模型中，未发现+869T>C多态性与CsA诱导的GO之间存在关联（TT+TC与CC相比：OR，0.77；95%CI，0.29 - 2.10；P = 0.614）。在隐性模型中，未发现+915G>C多态性与CsA诱导的GO之间存在关联（CC与GG+GC相比：OR，1.40；95%CI，0.81 - 2.43；P = 0.225）。并且在显性模型中，肾移植受者的MDR1 C3435T基因多态性与CsA诱导的GO之间未计算出显著性差异（TT与CC+CT相比：OR，1.14；95%CI，0.62 - 2.09；P = 0.68）。
TGF-β1 +869T>C、+915G>C和MDR1 C3435T基因多态性与肾移植受者中CsA诱导的GO发病机制之间不存在显著关联。
