Bu Ruofei, Balakrishnan Santosh, Iftimia Nicusor, Price Hillel, Zdanski Carlton, Oldenburg Amy L
Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3216, USA.
Physical Sciences Inc., New England Business Center, Andover, MA 01810, USA.
Biomed Opt Express. 2017 Mar 15;8(4):2195-2209. doi: 10.1364/BOE.8.002195. eCollection 2017 Apr 1.
Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to quantify airway cross-sectional compliance (CC) by measuring changes in the luminal cross-sectional area (CSA) under physiologically relevant pressures of 10-40 cmHO. The accuracy and precision of CC measurements are determined using simulations of non-uniform rotation distortion (NURD) endemic to endoscopic scanning, and experiments performed in a simplified tube phantom and porcine tracheas. NURD simulations show that CC measurements are typically more accurate than that of the CSAs from which they are derived. Phantom measurements of CSA versus pressure exhibit high linearity (>0.99), validating the dynamic range of the SSaOCT system. Tracheas also exhibited high linearity ( = 0.98) suggestive of linear elasticity, while CC measurements were obtained with typically ± 12% standard error.
气道顺应性的量化可通过检测易塌陷区域来辅助阻塞性气道疾病的诊断和治疗。在此，我们评估扫频源解剖光学相干断层扫描（SSaOCT）系统通过测量在10 - 40 cmH₂O生理相关压力下管腔横截面积（CSA）的变化来量化气道横截面顺应性（CC）的能力。使用针对内镜扫描特有的非均匀旋转畸变（NURD）模拟以及在简化管模型和猪气管中进行的实验来确定CC测量的准确性和精密度。NURD模拟表明，CC测量通常比其衍生的CSA测量更准确。CSA与压力的模型测量显示出高线性度（>0.99），验证了SSaOCT系统的动态范围。气管也表现出高线性度（r = 0.98），提示线性弹性，而CC测量的标准误差通常为±12%。
