Method for retrospective, respiratory-gated, anatomical optical coherence tomography for airway wall elastography.

SIGNIFICANCE

Airway wall elastography (AWE) is promising for evaluating upper airway obstructive disorders and airway injuries. Technologies for AWE based on endoscopic optical coherence tomography (OCT) provide micron-scale resolution to capture airway wall deformations during tidal breathing. Combined with an intraluminal pressure probe, these technologies can provide quantitative AWE as part of a routine bronchoscopy exam. However, scan times must be of short duration to mitigate risk.

AIM

Our objective is to reduce the scan time necessary to perform OCT elastography over a 50 mm length of the airway wall to less than 1 min.

APPROACH

We introduce an innovative, 4D OCT imaging technique that scans in a sawtooth pattern to revisit each axial position of the airway over a diversity of respiratory phases. An anatomical (long-range) OCT system capable of capturing cross-sections of the upper airway was employed in conjunction with an intraluminal pressure catheter. Scanned data are retrospectively sorted into axial bins with high- and low-pressure thresholds used to compute cross-sectional compliance (CC) within each bin across the length of the upper airway.

RESULTS

4D OCT was tested in simulation, on rigid and deformable samples, and on pigs undergoing bronchoscopy. A precise CC measurement with a 0.5 mm sampling resolution over a 50 mm scan length in under 42 s was achieved.

CONCLUSIONS

The retrospective, respiratory-gated 4D aOCT scanning method is a minimally invasive technique for measuring airway wall CC. The method exhibited high precision in controlled models, effectively detected elastic heterogeneity, and yielded clinically relevant results in pigs.