通过光声断层扫描对胶原酶诱导的脑出血进行无创体内监测。
Noninvasive in vivo monitoring of collagenase induced intracerebral hemorrhage by photoacoustic tomography.
作者信息
Wu Dan, Yang Jinge, Zhang Guang, Jiang Huabei
机构信息
School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Center for Information in Biomedicine, University of Electronic Science and Technology of China, Sichuan, China.
出版信息
Biomed Opt Express. 2017 Mar 21;8(4):2276-2286. doi: 10.1364/BOE.8.002276. eCollection 2017 Apr 1.
Abstract
Photoacoustic tomography (PAT) is an emerging noninvasive biomedical imaging modality that can be used for visualizing the structure and function of brain in high resolution. Here we report an application of PAT to imaging intracerebral hemorrhage (ICH) in a mouse model. In vivo photoacoustic images were obtained in mice with right basal ganglia hemorrhage induced by microinjection of collagenase. With multi-spectral light excitation, cortical vascular network was clearly revealed at 532 nm, and ICH associated hematoma lesions and perihemmatoma regions were accurately mapped over time at 750 nm and 875 nm, respectively. Our results suggest that PAT provides a unique tool for visualizing hemodynamics involved in brain diseases such as ICH.
摘要
光声断层扫描（PAT）是一种新兴的非侵入性生物医学成像模态，可用于高分辨率可视化大脑的结构和功能。在此，我们报告PAT在小鼠模型中对脑内出血（ICH）成像的应用。通过显微注射胶原酶诱导右侧基底节出血的小鼠获得了体内光声图像。在多光谱光激发下，在532nm处清晰显示了皮质血管网络，在750nm和875nm处分别随时间准确绘制了ICH相关的血肿病变和血肿周围区域。我们的结果表明，PAT为可视化诸如ICH等脑部疾病中涉及的血流动力学提供了一种独特的工具。
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