de Zegher Francis, Reinehr Thomas, Malpique Rita, Darendeliler Feyza, López-Bermejo Abel, Ibáñez Lourdes
Department of Development and Regeneration, University of Leuven, Leuven, Belgium.
Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany.
Obesity (Silver Spring). 2017 Sep;25(9):1486-1489. doi: 10.1002/oby.21935. Epub 2017 Jul 24.
Hepato-visceral fat excess is a feature of polycystic ovary syndrome (PCOS). Risk factors for such excess include low prenatal weight gain and high postnatal weight gain. This study examined whether adolescent PCOS was preceded by a relatively low birth weight and/or a relatively high BMI at diagnosis.
Study participants included 467 girls with PCOS (298 without obesity and 169 with obesity), diagnosed, respectively, in Spain and Germany; 87 healthy girls were controls. Z scores for weight at birth and BMI at PCOS diagnosis were derived, and their differences were calculated.
Spanish girls with PCOS and without obesity and German girls with PCOS and obesity had mean birth weight z scores of -0.7 and 0.0, respectively, and mean BMI z scores of + 0.4 and +2.7, respectively, so that mean z score increments amounted to +1.1 and +2.6 (P < 0.001 vs. controls).
PCOS in adolescent girls was preceded by marked z score increments between weight at birth and BMI at PCOS diagnosis, thus corroborating the notion that PCOS development is driven by a mismatch between prenatal weight gain and postnatal weight gain.
肝内脏脂肪过多是多囊卵巢综合征（PCOS）的一个特征。这种脂肪过多的风险因素包括孕期体重增加少和产后体重增加多。本研究调查了青少年多囊卵巢综合征患者在诊断时是否出生体重相对较低和/或体重指数（BMI）相对较高。
研究参与者包括467名分别在西班牙和德国被诊断为多囊卵巢综合征的女孩（298名无肥胖，169名有肥胖）；87名健康女孩作为对照。得出出生体重的Z分数和多囊卵巢综合征诊断时的BMI的Z分数，并计算它们之间的差异。
西班牙无肥胖的多囊卵巢综合征女孩和德国有肥胖的多囊卵巢综合征女孩出生体重的平均Z分数分别为-0.7和0.0，BMI的平均Z分数分别为+0.4和+2.7，因此平均Z分数增量分别为+1.1和+2.6（与对照组相比，P<0.001）。
青少年女孩的多囊卵巢综合征在出生体重与多囊卵巢综合征诊断时的BMI之间有明显的Z分数增量，从而证实了多囊卵巢综合征的发生是由孕期体重增加与产后体重增加不匹配所驱动的这一观点。
