Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Department of Diabetes and Vascular Medicine, Monash Health, Melbourne, Victoria, Australia.
Clin Endocrinol (Oxf). 2022 Aug;97(2):165-173. doi: 10.1111/cen.14757. Epub 2022 May 30.
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting 8%-13% of reproductive-aged women. The aetiology of the syndrome is complex, with genetic susceptibility, androgen exposure in early life and adiposity related dysfunction leading to perturbance in hypothalamic-ovarian function. PCOS clinical features are heterogeneous, with manifestations arising even in early adolescence, developing into multisystem reproductive, metabolic and psychological manifestations in adulthood. In this review, we will discuss challenges in the diagnosis of PCOS and understanding of the natural history of PCOS.
多囊卵巢综合征（PCOS）是最常见的影响 8%-13%育龄妇女的内分泌疾病。该综合征的病因复杂，具有遗传易感性、生命早期雄激素暴露和肥胖相关的功能障碍，导致下丘脑-卵巢功能紊乱。PCOS 的临床特征具有异质性，即使在青春期早期也会出现表现，在成年后发展为多系统生殖、代谢和心理表现。在这篇综述中，我们将讨论 PCOS 的诊断挑战和对 PCOS 自然史的理解。
