a Department of Preventive Medicine , Bengbu medical college , Bengbu , Anhui Province , China.
b Department of public health , Bengbu Health Board , Bengbu , Anhui Province , China.
Clin Exp Hypertens. 2017;39(8):732-739. doi: 10.1080/10641963.2017.1324477. Epub 2017 Jul 24.
To investigate the association between triglyceride-glucose(TyG) index and the risk of hypertension.
A cross-sectional study was conducted in Bengbu, China. The participants received relevant questionnaire survey, anthropometric tests, and laboratory examination. Multivariate logistic regression analysis was performed to estimate the possible association between TyG index and hypertension risk. The additive interaction evaluated by the relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index(SI) was calculated.
A total of 1777 participants (748 men and 1029 women) were investigated. There was a significant increase in the risk of hypertension and isolated systolic hypertension (ISH) when comparing the highest TyG index (the fourth quartile) to the lowest TyG index (the first quartile) and corresponding ORs were 2.446 (95% CI: 1.746-3.426) and 2.621(95%CI: 1.627-4.224), respectively. However, no significant relationship was observed between TyG index and isolated diastolic hypertension (IDH). In males, significant interactions between TyG index and WHtR (RERI:1.978, 95%CI: 0.162-3.792; AP: 0.359, 0.113-0.605; SI:1.782, 1.017-3.122), smoking (AP: 0.437, 95%CI: 0.048-0.825), family history of hypertension (AP:0.433, 95%CI: 0.203-0.662; SI:2.248, 95%CI: 1.333-3.791) were observed. As for females, there were also significant interactions between TyG index and WHtR (RERI:1.415, 95%CI: 0.693-2.136; AP: 0.198, 95%CI: 0.104-0.291; SI:1.298, 95%CI:1.101-1.530), family history of hypertension (RERI:1.744, 95%CI: 0.221-3.267; AP:0.405, 95%CI: 0.113-0.697) on risk of hypertension.
Increased TyG index was significantly associated with higher risk of hypertension and ISH, but not for IDH in middle-aged and elderly adults. Our results also demonstrated interactions of TyG index and abdominal obesity and family history of hypertension on hypertension risk.
探讨甘油三酯-葡萄糖（TyG）指数与高血压风险的关系。
本研究为横断面研究，在中国蚌埠进行。参与者接受了相关的问卷调查、人体测量测试和实验室检查。采用多变量 logistic 回归分析来估计 TyG 指数与高血压风险之间的可能关联。通过相对超额风险归因（RERI）、归因比例（AP）和协同指数（SI）来评估加性交互作用。
共纳入 1777 名参与者（748 名男性和 1029 名女性）。与最低 TyG 指数（第一四分位数）相比，最高 TyG 指数（第四四分位数）的高血压和单纯收缩期高血压（ISH）风险显著增加，相应的 OR 值分别为 2.446（95%CI：1.746-3.426）和 2.621（95%CI：1.627-4.224）。然而，TyG 指数与单纯舒张期高血压（IDH）之间没有显著关系。在男性中，TyG 指数与 WHtR（RERI：1.978，95%CI：0.162-3.792；AP：0.359，0.113-0.605；SI：1.782，1.017-3.122）、吸烟（AP：0.437，95%CI：0.048-0.825）和高血压家族史（AP：0.433，95%CI：0.203-0.662；SI：2.248，95%CI：1.333-3.791）之间存在显著交互作用。对于女性，TyG 指数与 WHtR（RERI：1.415，95%CI：0.693-2.136；AP：0.198，95%CI：0.104-0.291；SI：1.298，95%CI：1.101-1.530）和高血压家族史（RERI：1.744，95%CI：0.221-3.267；AP：0.405，95%CI：0.113-0.697）之间也存在显著的交互作用，与高血压风险相关。
在中老年人中，较高的 TyG 指数与高血压和 ISH 的风险显著相关，但与 IDH 无关。我们的研究结果还表明，TyG 指数与腹部肥胖和高血压家族史之间存在交互作用，与高血压风险相关。
