Wu Lanlan, Huang Zheng
Department of Cardiology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510120, China.
Sci Rep. 2024 Dec 28;14(1):31352. doi: 10.1038/s41598-024-82881-y.
The cardiovascular kidney metabolic (CKM) syndrome is a dynamic geriatric condition that has received limited research attention regarding its potential associations with the triglyceride glucose (TyG) index. This study aims to explore the potential association between the TyG index and advanced CKM syndrome. Data for this cross-sectional study were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018. The association between the TyG index and the risk of advanced CKM syndrome was investigated using multivariable logistic regression models. Additionally, a restricted cubic spline (RCS) analysis was employed to assess the dose-response relationship between the TyG index and the risk of advanced CKM syndrome. A total of 7904 participants were included in this study, with a mean TyG index of 5.04 ± 0.41. The prevalence of advanced CKM syndrome among the participants was 14.85%. Our findings indicated that as the TyG index quartiles increased, the risk of advanced CKM syndrome also increased. The results from the three regression analysis models indicated a positive association between the continuous TyG index and advanced CKM syndrome. Furthermore, the quartiles of the TyG index were significantly associated with an increased prevalence of advanced CKM syndrome in the fully adjusted models (TyG index Q4 vs. Q1, OR = 1.94, 95% CI 1.37-2.75, P < 0.001). The results of the RCS analysis indicated a linear and positive association between the TyG index and advanced CKM syndrome. The results indicated that elevated TyG index is associated with an increased prevalence of advanced CKM syndrome. This suggests that the TyG index may be a useful tool for assessing the risk of advanced CKM syndrome.
心血管-肾脏-代谢（CKM）综合征是一种动态的老年疾病，关于其与甘油三酯-葡萄糖（TyG）指数的潜在关联，目前的研究关注有限。本研究旨在探讨TyG指数与晚期CKM综合征之间的潜在关联。这项横断面研究的数据来自2011年至2018年进行的美国国家健康与营养检查调查（NHANES）。使用多变量逻辑回归模型研究TyG指数与晚期CKM综合征风险之间的关联。此外，采用受限立方样条（RCS）分析来评估TyG指数与晚期CKM综合征风险之间的剂量反应关系。本研究共纳入7904名参与者，平均TyG指数为5.04±0.41。参与者中晚期CKM综合征的患病率为14.85%。我们的研究结果表明，随着TyG指数四分位数的增加，晚期CKM综合征的风险也增加。三个回归分析模型的结果表明，连续的TyG指数与晚期CKM综合征之间存在正相关。此外，在完全调整模型中，TyG指数四分位数与晚期CKM综合征患病率增加显著相关（TyG指数Q4与Q1相比，OR=1.94，95%CI 1.37-2.75，P<0.001）。RCS分析结果表明，TyG指数与晚期CKM综合征之间存在线性正相关。结果表明，TyG指数升高与晚期CKM综合征患病率增加相关。这表明TyG指数可能是评估晚期CKM综合征风险的有用工具。
