Wagenlehner Florian, Wullt Björn, Ballarini Stefania, Zingg Daniel, Naber Kurt G
a Clinic for Urology, Pediatric Urology and Andrology , Justus-Liebig University , Giessen , Germany.
b Section of MIG , Lund University , Lund , Sweden.
Expert Rev Pharmacoecon Outcomes Res. 2018 Feb;18(1):107-117. doi: 10.1080/14737167.2017.1359543. Epub 2017 Jul 31.
Uncomplicated lower urinary tract infections (UTIs) occur in approximately 50% of women, and 20-30% experience recurrent UTI. Data on UTIs and quality of life (QoL) in Europe are limited.
This was an anonymous, self-administered web-based survey conducted in 5 countries (Germany, Switzerland, Poland, Russia and Italy), on adult women who had experienced recurrent UTI and were affected by acute UTI currently or within 4 weeks of study entry. Questions covered disease course; management; social and economic burden; education, income, and health insurance status. QoL was evaluated using the SF-12v2.
Participants reported a mean of 5.15 UTI symptoms, ranging from 4.85 - 5.38 in Russia and Germany. There was a mean of 2.78 doctor visits per year (1.74 - 3.71 in Russia and Germany; p < 0.0001). 80.3% of participants had been treated with antibiotics, mean prescriptions ranged from 2.17 (Poland) to 3.36 (Germany) per person per year. A mean of 3.09 days sick leave due to UTIs, and 3.45 days of limited activities, were reported. Although 73.8% of participants had tried prophylaxis recurrence was common and associated with mental stress for a high proportion of women.
Our results indicate that recurrent UTIs have a significant impact on QoL of women in Europe.
约50%的女性会发生单纯性下尿路感染（UTI），其中20%-30%会经历复发性UTI。欧洲关于UTI与生活质量（QoL）的数据有限。
这是一项在5个国家（德国、瑞士、波兰、俄罗斯和意大利）开展的基于网络的匿名自填式调查，对象为有复发性UTI病史且在研究入组时或入组后4周内患有急性UTI的成年女性。问题涵盖疾病病程、治疗、社会和经济负担、教育程度、收入及医疗保险状况。使用SF-12v2评估生活质量。
参与者报告的UTI症状平均为5.15种，在俄罗斯和德国为4.85 - 5.38种。每年平均看医生2.78次（俄罗斯和德国为1.74 - 3.71次；p < 0.0001）。80.3%的参与者接受过抗生素治疗，每人每年的平均处方量从2.17（波兰）到3.36（德国）不等。因UTI平均请病假3.09天，活动受限3.45天。尽管73.8%的参与者尝试过预防措施，但复发很常见，且对很大一部分女性来说与精神压力有关。
我们的结果表明，复发性UTI对欧洲女性的生活质量有重大影响。
