一种作为金属β-内酰胺酶强效抑制剂的DNA纳米带。
A DNA nanoribbon as a potent inhibitor of metallo-β-lactamases.
作者信息
Ouyang Xiangyuan, Chang Ya-Nan, Yang Ke-Wu, Wang Wen-Ming, Bai Jian-Jian, Wang Jian-Wei, Zhang Yue-Juan, Wang Si-Yao, Xie Bin-Bin, Wang Li-Li
机构信息
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education of China, Key Laboratory of Modern Separation Science in Shaanxi Province, College of Chemistry & Material Science, Northwest University, Xi'an, 710127, China.
出版信息
Chem Commun (Camb). 2017 Aug 3;53(63):8878-8881. doi: 10.1039/c7cc04483f.
We discovered a promising metallo-β-lactamase inhibitor, a DNA nanoribbon, by enzymatic kinetics and isothermal titration calorimetry evaluations. Atomic force microscopy, gel electrophoresis, competitive binding experiments, circular dichroic and thermal denaturation studies suggested that the DNA nanoribbon could bind to the enzyme through a minor groove.
通过酶动力学和等温滴定量热法评估，我们发现了一种有前景的金属β-内酰胺酶抑制剂——一种DNA纳米带。原子力显微镜、凝胶电泳、竞争性结合实验、圆二色性和热变性研究表明，该DNA纳米带可通过小沟与酶结合。
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