Jiang Aihua, Zhao Huishan, Liu Xiaofei, Yu Mingwei, Chen Jian, Jiang Wen G
Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
Cardiff-China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.
Anticancer Res. 2017 Aug;37(8):4371-4378. doi: 10.21873/anticanres.11831.
BACKGROUND/AIM: Muscle relaxants, also known as neuromuscular blocking agents, can block nerve impulses to the muscles and are always used in surgery for general anesthesia. However, the effect of muscle-relaxant anesthetics on cell activity in gastric cancer is currently unknown. The present study aimed to examine and compare the role of three different muscle-relaxant anesthetics in gastric cancer cells.
Gastric cancer cells (SGC7901 and BGC 823) were treated with a different dose of muscle-relaxant anesthetics, Rocuronium bromide (Rb), Vecuronium bromide (Vb) and Cisatracurium Besilate (CB). Using in vitro models, the effects on gastric cancer cell invasion, growth and migration of various anesthetics were subsequently investigated.
We found that Rb increased the growth, invasion and migration of gastric cancer cells SGC7901 and BGC823. However, Vb and CB, as relatively mitigative anesthetics, did not significantly affect gastric cancer cell malignant phenotype at their regular blood concentration.
Our results are important in selecting the type and dose of anesthetic used for surgery of gastric cancer patients. An understanding of the effect of muscle-relaxant anesthetics and their impact on tumor metastasis is critical, since it provides insight into the appropriate anesthetic strategy that could improve long-term survival in some patients with gastric cancer.
背景/目的：肌肉松弛剂，也被称为神经肌肉阻滞剂，可阻断神经向肌肉传递的冲动，常用于外科手术的全身麻醉。然而，目前尚不清楚肌肉松弛剂类麻醉药对胃癌细胞活性的影响。本研究旨在检测和比较三种不同的肌肉松弛剂类麻醉药在胃癌细胞中的作用。
用不同剂量的肌肉松弛剂类麻醉药，即罗库溴铵（Rb）、维库溴铵（Vb）和顺式阿曲库铵（CB）处理胃癌细胞（SGC7901和BGC 823）。随后利用体外模型研究了各种麻醉药对胃癌细胞侵袭、生长和迁移的影响。
我们发现Rb可促进胃癌细胞SGC7901和BGC823的生长、侵袭和迁移。然而，Vb和CB作为相对温和的麻醉药，在常规血药浓度下对胃癌细胞的恶性表型没有显著影响。
我们的研究结果对于选择用于胃癌患者手术的麻醉药类型和剂量具有重要意义。了解肌肉松弛剂类麻醉药的作用及其对肿瘤转移的影响至关重要，因为这有助于深入了解合适的麻醉策略，从而可能提高部分胃癌患者的长期生存率。
