Liu Liyan, Zhao Huishan, Sheng Lin, Yang Ping, Zhou Huihui, Wang Ruizheng
The Fifth People's Hospital of Ji'nan, Jinan, P.R. China.
Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
Anticancer Res. 2017 Aug;37(8):4569-4573. doi: 10.21873/anticanres.11855.
BACKGROUND/AIM: Collision of Epstein-Barr virus (EBV)-associated lymphoepithelioma-like carcinoma (LELC) with non-Hodgkin's lymphoma of the stomach is extremely rare.
Herein we report a case of LELC with primary diffuse large B-cell lymphoma (DLBCL) of the stomach in a 65-year-old patient.
Gastric endoscopy showed a poorly differentiated adenocarcinoma of the stomach. The patient underwent radical gastrectomy, and histopathological examinations revealed the collision of LELC and DLBCL of the stomach. In situ hybridization showed that most carcinoma cells of LELC were positive for EBV-encoded small RNA (EBER) suggesting that the virus infection happened in the early stage of tumorigenesis, while DLBCL was negative.
This is the first report of collision of EBV-associated LELC with primary DLBCL of the stomach.
背景/目的：爱泼斯坦-巴尔病毒（EBV）相关的淋巴上皮瘤样癌（LELC）与胃非霍奇金淋巴瘤的碰撞极为罕见。
在此，我们报告一例65岁患者的LELC合并胃原发性弥漫性大B细胞淋巴瘤（DLBCL）的病例。
胃镜检查显示胃低分化腺癌。患者接受了根治性胃切除术，组织病理学检查显示胃LELC与DLBCL碰撞。原位杂交显示，LELC的大多数癌细胞EBV编码小RNA（EBER）呈阳性，提示病毒感染发生在肿瘤发生的早期，而DLBCL为阴性。
这是EBV相关LELC与胃原发性DLBCL碰撞的首例报告。
