Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
J Am Acad Dermatol. 2010 Apr;62(4):681-4. doi: 10.1016/j.jaad.2008.07.024.
Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare cutaneous neoplasm with histopathologic similarities to nasopharyngeal carcinoma. The association of nasopharyngeal carcinoma with Epstein-Barr virus (EBV) is well documented. EBV has also been reported to be associated with LELC in only four sites (the stomach, salivary glands, lung, and thymus), but not in the skin. We report herein a case of EBV-positive LELCS. An 82-year-old female presented with a red nodule on the right cheek. Histologically, the entire dermis was occupied by atypical tumor cell nests with dense lymphocytic infiltration. Neoplastic cells were strongly positive for cytokeratin 14 but were negative for cytokeratins 19 and 20. EBV genomes in neoplastic cells were detected by polymerase chain reaction analysis and in situ hybridization for EBV-encoded RNA, suggesting an association with EBV.
皮肤淋巴上皮样癌（LELCS）是一种罕见的皮肤肿瘤，其组织病理学与鼻咽癌相似。鼻咽癌与 Epstein-Barr 病毒（EBV）的关联已有充分的文献记载。仅在四个部位（胃、唾液腺、肺和胸腺）报道 EBV 与 LELC 有关，而不在皮肤中。我们在此报告一例 EBV 阳性的 LELCS。一位 82 岁女性因右侧脸颊出现红色结节就诊。组织学上，整个真皮被弥漫性淋巴细胞浸润的不典型肿瘤细胞巢占据。肿瘤细胞强烈表达细胞角蛋白 14，但不表达细胞角蛋白 19 和 20。通过聚合酶链反应分析和 EBV 编码 RNA 的原位杂交检测到肿瘤细胞中存在 EBV 基因组，提示与 EBV 有关。
