不同姑息性减黄方法对晚期恶性梗阻性黄疸患者免疫功能的影响
Effects of Different Palliative Jaundice Reducing Methods on Immunologic Functions in Patients with Advanced Malignant Obstructive Jaundice.
作者信息
Tang Kun, Sui Lu-Lu, Xu Gang, Zhang Tong, Liu Qiang, Liu Xiao-Fang
机构信息
Department of Hepatobiliary Surgery, Affiliated Yantai Yuhuangding Hospital, Qingdao University Medical College, Yantai, P.R. China.
Department of Hepatobiliary Surgery, Affiliated Yantai Yuhuangding Hospital, Qingdao University Medical College, Yantai, P.R. China
出版信息
Anticancer Res. 2017 Aug;37(8):4665-4670. doi: 10.21873/anticanres.11870.
BACKGROUND/AIM: This study aimed to investigate the effects of three treatment methods on the immunological function of patients with advanced malignant obstructive jaundice (MOJ).
PATIENTS AND METHODS
Patients with advanced MOJ were randomly divided into three groups according to biliary drainage methods. Detection of levels of multi-indices were investigated in different time periods.
RESULTS
After drainage, the levels of complement 3 (C3) and complement 4 (C4) were increased. Forteen days post-operation, the levels of immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) in the group undergoing palliative surgery decreased significantly compared to those in both percutaneous transhepatic cholangio drainage (PTCD) and endoscopic retrograde biliary drainage (ERBD) groups. The level of serum endotoxin in the group undergoing palliative surgery decreased gradually.
CONCLUSION
Palliative surgery for reducing jaundice is superior to PTCD and ERBD in improving immune function of patients with MOJ.
背景/目的：本研究旨在探讨三种治疗方法对晚期恶性梗阻性黄疸（MOJ）患者免疫功能的影响。
患者与方法
晚期MOJ患者根据胆道引流方法随机分为三组。在不同时间段检测多项指标水平。
结果
引流后，补体3（C3）和补体4（C4）水平升高。术后14天，姑息性手术组的免疫球蛋白G（IgG）、免疫球蛋白A（IgA）和免疫球蛋白M（IgM）水平与经皮经肝胆道引流（PTCD）组和内镜逆行胆道引流（ERBD）组相比显著降低。姑息性手术组血清内毒素水平逐渐降低。
结论
在改善MOJ患者免疫功能方面，减黄的姑息性手术优于PTCD和ERBD。
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