Department of Cardiology, Peking University First Hospital, Beijing, 100034, China.
Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, 100191, China.
Sci Rep. 2018 Feb 19;8(1):3229. doi: 10.1038/s41598-018-21023-7.
Central blood pressure level is not always consistent with peripheral blood pressure level, and especially their joint effect on incident hypertension is not well established. A total of 1607 non-hypertensive subjects from an atherosclerosis cohort in Beijing, China were included. Central systolic blood pressure (cSBP) was obtained using Omron HEM-9000AI machine and peripheral systolic blood pressure (pSBP) was measured using Omron HEM-7117 electronic sphygmomanometer, separately. Hypertension was defined as BP ≥ 140/90 mmHg or self-reported hypertension or taking any antihypertension drugs at the follow-up survey. After a median follow-up of 2.3 years, incident hypertension was 13.1%. Every 1 standard deviation increase of cSBP and pSBP was associated with 1.98 (95%CI: 1.69-2.33) and 2.84 (95%CI: 2.30-3.52) times of incident hypertension after adjustment for confounders. Moreover, hypertension risk in single pSBP ≥ 120 mmHg group, single cSBP ≥ 120 mmHg group, and both pSBP and cSBP ≥ 120 mmHg group was 2.83 (95%CI: 0.98-8.16), 3.28 (95%CI: 1.24-8.70), and 11.47 (95%CI: 4.97-26.46) times higher than both pSBP and cSBP < 120 mmHg group, respectively. The joint effect of cSBP and pSBP is superior to either cSBP or pSBP to predict incident hypertension in a Chinese community-based population. Screening of central blood pressure should be considered in non-hypertensive population for the purpose of primary intervention, especially for subjects with pSBP ≥ 120 mmHg.
中心血压水平并不总是与外周血压水平一致，特别是它们对高血压事件的联合作用尚未得到很好的证实。本研究共纳入了来自中国北京动脉粥样硬化队列中的 1607 名非高血压受试者。使用欧姆龙 HEM-9000AI 机器测量中心收缩压(cSBP)，使用欧姆龙 HEM-7117 电子血压计测量外周收缩压(pSBP)。高血压的定义为血压≥140/90mmHg，或随访时自我报告患有高血压或服用任何降压药物。中位随访 2.3 年后，新发高血压为 13.1%。在校正混杂因素后，cSBP 和 pSBP 每增加 1 个标准差，与新发高血压的风险分别增加 1.98(95%CI:1.69-2.33)和 2.84(95%CI:2.30-3.52)倍。此外，在单独的 pSBP≥120mmHg 组、单独的 cSBP≥120mmHg 组和 pSBP 和 cSBP 均≥120mmHg 组中，高血压的风险分别为 2.83(95%CI:0.98-8.16)、3.28(95%CI:1.24-8.70)和 11.47(95%CI:4.97-26.46)倍，高于 pSBP 和 cSBP<120mmHg 组。在中国人群中，中心血压和外周血压的联合作用优于中心血压或外周血压，可预测新发高血压。对于非高血压人群，应考虑筛查中心血压，以便进行早期干预，尤其是对于 pSBP≥120mmHg 的人群。
