Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Whiteknights, Reading, RG6 6AP, UK.
School of Life and Medical Sciences, University of Hertfordshire, College Lane, Hatfield, AL10 9AB, UK.
Sci Rep. 2017 Jul 24;7(1):6274. doi: 10.1038/s41598-017-05802-2.
Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.
与代谢综合征（MetS）相关的代谢标志物可能受到 APOE 基因型与血浆脂肪酸（FA）之间相互作用的影响。在这项研究中，我们探讨了错义 APOE 多态性与 FA 状态之间的 FA-基因相互作用对 MetS 中代谢标志物的影响。在 442 名 MetS 患者（LIPGENE 研究）中，我们在基线时和 12 周随机、对照、平行的膳食 FA 干预后测定了血浆 FA、血压、胰岛素敏感性和血脂浓度。使用调整后的一般线性模型评估了基线和血浆 FA 变化时 FA-APOE 基因相互作用。在基线时，E4 携带者的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和载脂蛋白 B（apo B）的血浆浓度高于 E2 携带者；E4 携带者的 TC、LDL-C 和 apo B 也高于 E3/E3。虽然升高的血浆 n-3 多不饱和脂肪酸（PUFA）与 E2 携带者中 apo CIII 浓度的有益降低有关，但高比例的血浆 C16:0 与 E4 携带者的胰岛素抵抗有关。在 FA 干预后，血浆长链 n-3 PUFA 的减少与 E2 携带者中 apo CII 浓度的降低有关。我们的新数据表明，MetS 患者可能受益于基于 APOE 基因型的个性化饮食干预。
