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评估高分辨率超声在体外溶栓过程中评估血栓 3D 体积的应用。

Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis.

机构信息

UMR Inserm U930, Université François-Rabelais de Tours, Tours, France.

CHRU de Tours; INSERM CIC 1415, 37000, Tours, France.

出版信息

Sci Rep. 2017 Jul 24;7(1):6211. doi: 10.1038/s41598-017-06089-z.

DOI:10.1038/s41598-017-06089-z
PMID:28740129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5524902/
Abstract

Thrombosis is a major cause of several diseases, i.e. myocardial infarction, cerebral stroke and pulmonary embolism. Thrombolytic therapies are required to induce fast and efficient recanalization of occluded vessels. To evaluate the in vitro efficacy of these thrombolytic strategies, measuring clot dissolution is essential. This study aimed to evaluate and validate high resolution ultrasound as a tool to assess the exact volume of clots in 3D and in real time during in vitro thrombolytic drug testing. This new method was validated by measuring the effects of concentration range of recombinant tissue type plasminogen activator on a blood clot during complete occlusion or 70% stenosis of a vessel. This study shows that high resolution ultrasound imaging allows for a real-time assessment of the 3D volume of a blood clot with negligible inter- and intra-operator variabilities. The conclusions drawn from this study demonstrate the promising potential of high resolution ultrasound imaging for the in vitro assessment of new thrombolytic drugs.

摘要

血栓形成是多种疾病的主要原因，例如心肌梗死、脑卒中和肺栓塞。需要溶栓疗法来快速有效地使闭塞的血管再通。为了评估这些溶栓策略的体外疗效，测量血栓溶解至关重要。本研究旨在评估和验证高分辨率超声作为一种工具，用于在体外溶栓药物测试过程中实时评估 3D 中血栓的确切体积。通过测量重组组织型纤溶酶原激活剂的浓度范围对完全闭塞或血管 70%狭窄时的血栓的影响来验证这种新方法。本研究表明，高分辨率超声成像允许实时评估血栓的 3D 体积，且操作者间和操作者内的可变性可忽略不计。本研究得出的结论表明，高分辨率超声成像对于新溶栓药物的体外评估具有很大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/23e35600d040/41598_2017_6089_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/647f87ce36a2/41598_2017_6089_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/ec9100916520/41598_2017_6089_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/6682358252a1/41598_2017_6089_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/11f8be2f6135/41598_2017_6089_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/b97cb5c526f7/41598_2017_6089_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/23e35600d040/41598_2017_6089_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/647f87ce36a2/41598_2017_6089_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/ec9100916520/41598_2017_6089_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/6682358252a1/41598_2017_6089_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/11f8be2f6135/41598_2017_6089_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/b97cb5c526f7/41598_2017_6089_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ebb/5524902/23e35600d040/41598_2017_6089_Fig6_HTML.jpg

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本文引用的文献

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Ultraschall Med. 2017 Jan;38(1):83-84. doi: 10.1055/s-0035-1553322. Epub 2015 Sep 2.
2
Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.血管内溶栓联合支架取栓与单纯静脉溶栓治疗脑卒中的比较。
N Engl J Med. 2015 Jun 11;372(24):2285-95. doi: 10.1056/NEJMoa1415061. Epub 2015 Apr 17.
3
Sonothrombolysis: the contribution of stable and inertial cavitation to clot lysis.
使用多普勒超声彩色和运动模式技术通过血管模型对一种最新研发的人造血液进行兼容性和验证研究。
J Med Ultrasound. 2020 Apr 23;28(4):219-224. doi: 10.4103/JMU.JMU_116_19. eCollection 2020 Oct-Dec.
超声溶栓：稳态空化和惯性空化对血栓溶解的作用
Ultrasound Med Biol. 2015 May;41(5):1402-10. doi: 10.1016/j.ultrasmedbio.2014.12.007. Epub 2015 Jan 15.
4
Chronologic echogenicity changes and histologic correlates in experimental blood clots: a serial sonographic study.实验性血肿块的时变回声改变及其组织学相关性：一项系列超声研究。
J Ultrasound Med. 2012 Dec;31(12):1987-92. doi: 10.7863/jum.2012.31.12.1987.
5
Volumetric quantification of in vitro sonothrombolysis with microbubbles using high-resolution optical coherence tomography.使用高分辨率光相干断层扫描技术对体外超声溶栓中微泡的容积定量分析。
J Biomed Opt. 2012 Jul;17(7):070502. doi: 10.1117/1.JBO.17.7.070502.
6
In vitro sonothrombolysis of human blood clots with BR38 microbubbles.BR38 微泡体外超声溶栓人血血栓。
Ultrasound Med Biol. 2012 Jul;38(7):1222-33. doi: 10.1016/j.ultrasmedbio.2012.02.023. Epub 2012 Apr 27.
7
Introduction of a new model for time-continuous and non-contact investigations of in-vitro thrombolysis under physiological flow conditions.介绍一种新的模型，用于在生理流动条件下进行时间连续和非接触式的体外溶栓研究。
BMC Neurol. 2011 May 26;11:58. doi: 10.1186/1471-2377-11-58.
8
The platelet-rich plasma clot: a standardized in-vitro clot formation protocol for investigations of sonothrombolysis under physiological flows.富血小板血浆凝块：一种用于在生理血流条件下研究超声溶栓的标准化体外凝块形成方案。
Blood Coagul Fibrinolysis. 2011 Jul;22(5):407-15. doi: 10.1097/MBC.0b013e3283468a60.
9
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Stroke. 2011 May;42(5):1237-43. doi: 10.1161/STROKEAHA.110.605576. Epub 2011 Mar 10.
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