Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Sci Rep. 2017 Jul 24;7(1):6227. doi: 10.1038/s41598-017-06606-0.
The study aims to examine the blood pressure (BP) trajectory during pregnancy and its association with pre-gravid BP level. In a pre-conception cohort study, newly-married women in Liuyang, China underwent pre-gravid measurements and were followed throughout the pregnancy. BP was measured at pre-conception and again throughout pregnancy. The functional principal component analysis was used to examine the trajectory of BP changes during pregnancy. A total of 1282 women with a singleton pregnancy who had both pre-conception and gestational BP measurements performed were included in the final analysis. The results showed that BP decreased significantly in early pregnancy and increased thereafter, without BP drop around 20 weeks of gestation. Pre-gravid BP level was inversely associated with the BP drop in early pregnancy, such that women with higher pre-gravid BP had greater BP drop at the beginning, while women with the lowest pre-gravid BP level demonstrated no obvious BP drop throughout the entire pregnancy.
本研究旨在探讨妊娠期间血压（BP）轨迹及其与孕前血压水平的关系。在一项前瞻性队列研究中，中国浏阳的新婚妇女在孕前进行了测量，并在整个孕期进行了随访。在孕前和整个孕期都测量了 BP。采用功能主成分分析方法来探讨妊娠期间 BP 变化的轨迹。共有 1282 名接受孕前和孕期 BP 测量的单胎妊娠妇女纳入最终分析。结果表明，BP 在孕早期显著下降，此后逐渐升高，孕 20 周左右无 BP 下降。孕前 BP 水平与孕早期 BP 下降呈负相关，即孕前 BP 较高的妇女在开始时 BP 下降幅度较大，而孕前 BP 水平最低的妇女在整个孕期 BP 下降不明显。
