Oishi S, Sasaki M, Sato T, Hirota Y, Takahashi M
Endocrinol Jpn. 1986 Jun;33(3):309-15. doi: 10.1507/endocrj1954.33.309.
131I-meta-iodobenzylguanidine (131I-MIBG) was also taken up by medullary thyroid carcinoma (MTC) as well as by pheochromocytoma in two patients with Sipple's syndrome. However, the mechanism of 131I-MIBG uptake by MTC has not been clarified yet. We measured tissue catecholamine levels in three MTC, since MTC can produce several active substances. Catecholamines were detected in various amounts in all MTC, but not in normal thyroid tissues. These findings suggest that MTC can produce catecholamines and therefore, 131I-MIBG is taken up and stored in catecholamine vesicles of MTC, like pheochromocytoma and neuroblastoma. We conclude that 131I-MIBG may be applied not only to diagnosis but also for the treatment of patients with MTC.
131I-间碘苄胍（131I-MIBG）在两名患有西普尔综合征的患者中被甲状腺髓样癌（MTC）以及嗜铬细胞瘤摄取。然而，MTC摄取131I-MIBG的机制尚未阐明。由于MTC可产生多种活性物质，我们测定了3例MTC组织中的儿茶酚胺水平。在所有MTC中均检测到不同量的儿茶酚胺，但在正常甲状腺组织中未检测到。这些发现表明MTC可产生儿茶酚胺，因此，131I-MIBG像嗜铬细胞瘤和神经母细胞瘤一样被摄取并储存在MTC的儿茶酚胺囊泡中。我们得出结论，131I-MIBG不仅可用于MTC患者的诊断，还可用于治疗。
