Poscente Michael D, Mintchev Martin P
Michael D Poscente, Martin P Mintchev, Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta T2N1N4, Canada.
World J Gastroenterol. 2017 Jul 7;23(25):4517-4528. doi: 10.3748/wjg.v23.i25.4517.
To enhance the clinical utility of electrogastrography (EGG), which has been recorded since 1922, but is clinically unutilized.
An innovative method to salvage the promise of EGG is proposed by introducing a preliminary procedure, while maintaining the electrodes, standardized equipment, and signal processing utilized in the well-established EGG testing of today. The proposed enhanced EGG (EEGG) protocol involves swallowing an ingestible capsule containing miniature electronic oscillator embedded in an expandable, self-disintegratable, biocompatible pseudobesoar residing in the stomach for the duration of the test. The benefits of the proposed approach are outlined, tested and discussed in details.
Experiments were performed on eight mongrel dogs (6F, 4M, 23.8 ± 3.3 kg). Four were administered an active EEGG capsule, while the rest were given a deactivated (battery removed) capsule. Pharmacologically facilitated gastric motility revealed a significant ( < 0.01) Pearson correlation between gastric motility indices obtained by force transducers implanted directly on the stomach, and the motility indices obtained by EEGG. A particular emphasis was made on preserving standard EGG-related hardware and software in order to facilitate the introduction of the proposed EEGG in environments which already utilize standard EGG testing. The expanded intragastric pseudobezoar containing the miniature electronic oscillator was retained during the tests, and could be disintegrated on demand.
Enhancing standard EGG by an ingestible, self-expanding and self-disintegrating pseudobesoar containing a miniature electronic oscillator can be an important avenue for clinical applicability of this test.
增强胃电图（EGG）的临床实用性。EGG自1922年以来就已被记录，但在临床上未得到应用。
通过引入一个初步程序，提出一种创新方法来挽救EGG的前景，同时保留当今成熟的EGG测试中所使用的电极、标准化设备和信号处理方式。所提出的增强型胃电图（EEGG）方案包括吞下一个可摄入胶囊，该胶囊包含一个微型电子振荡器，该振荡器嵌入一个可膨胀、可自行崩解、生物相容性的假胃石中，在测试期间位于胃内。详细概述、测试并讨论了所提出方法的益处。
对8只杂种犬（6只雌性，4只雄性，体重23.8±3.3千克）进行了实验。4只犬服用了活性EEGG胶囊，其余犬服用了失活（取出电池）的胶囊。药理学促进的胃动力显示，直接植入胃内的力传感器获得的胃动力指数与EEGG获得的动力指数之间存在显著（<0.01）的皮尔逊相关性。特别强调要保留与标准EGG相关的硬件和软件，以便于在已经使用标准EGG测试的环境中引入所提出的EEGG。测试期间，含有微型电子振荡器的膨胀胃内假胃石得以保留，并且可以根据需要崩解。
通过含有微型电子振荡器的可摄入、自膨胀和自崩解的假胃石来增强标准EGG，可能是该测试临床应用的一条重要途径。
