Schriber Roberta A, Anbari Zainab, Robins Richard W, Conger Rand D, Hastings Paul D, Guyer Amanda E
Center for Mind and Brain, University of California, Davis, CA.
Department of Psychology, University of California, Davis, CA.
Clin Psychol Sci. 2017 Jul;5(4):632-649. doi: 10.1177/2167702617699277. Epub 2017 May 13.
Recent models have focused on how brain-based individual differences in social sensitivity shape affective development in adolescence, when rates of depression escalate. Given the importance of the hippocampus in binding contextual and affective elements of experience, as well as its putative role in depression, we examined hippocampal volume as a moderator of the effects of social context on depressive symptoms in a sample of 209 Mexican-origin adolescents. Adolescents with larger versus smaller hippocampal volumes showed heightened sensitivity in their depressive symptoms to a protective factor inside the home (sense of family connectedness) and a risk factor outside of it (community crime exposure). These interactive effects uniquely predicted depressive symptoms and were greater for the left side, suggesting two independent social-contextual contributions to depression that were moderated by left hippocampal volume. Results elucidate complex brain-environment interplay in adolescent depression, offering clues about for whom and how social context plays a role.
最近的模型聚焦于在抑郁症发病率上升的青春期，基于大脑的社会敏感性个体差异如何塑造情感发展。鉴于海马体在整合情境与情感体验要素方面的重要性，以及其在抑郁症中可能发挥的作用，我们在209名墨西哥裔青少年样本中，将海马体体积作为社会环境对抑郁症状影响的调节因素进行了研究。海马体体积较大与较小的青少年，其抑郁症状对家庭内部的一个保护因素（家庭联结感）和外部的一个风险因素（社区犯罪暴露）表现出更高的敏感性。这些交互作用独特地预测了抑郁症状，且左侧的作用更大，这表明左侧海马体体积调节了对抑郁症产生影响的两种独立的社会情境因素。研究结果阐明了青少年抑郁症中复杂的脑-环境相互作用，为社会环境对谁以及如何发挥作用提供了线索。
