情绪唤醒对杏仁核-海马体连接的动态调节。
Dynamic modulation of amygdala-hippocampal connectivity by emotional arousal.
作者信息
Fastenrath Matthias, Coynel David, Spalek Klara, Milnik Annette, Gschwind Leo, Roozendaal Benno, Papassotiropoulos Andreas, de Quervain Dominique J F
机构信息
Division of Cognitive Neuroscience, Department of Psychology, University of Basel, 4055 Basel, Switzerland, Division of Molecular Neuroscience, Department of Psychology, University of Basel, 4055 Basel, Switzerland,
Division of Cognitive Neuroscience, Department of Psychology, University of Basel, 4055 Basel, Switzerland, Division of Molecular Neuroscience, Department of Psychology, University of Basel, 4055 Basel, Switzerland.
出版信息
J Neurosci. 2014 Oct 15;34(42):13935-47. doi: 10.1523/JNEUROSCI.0786-14.2014.
Positive and negative emotional events are better remembered than neutral events. Studies in animals suggest that this phenomenon depends on the influence of the amygdala upon the hippocampus. In humans, however, it is largely unknown how these two brain structures functionally interact and whether these interactions are similar between positive and negative information. Using dynamic causal modeling of fMRI data in 586 healthy subjects, we show that the strength of the connection from the amygdala to the hippocampus was rapidly and robustly increased during the encoding of both positive and negative pictures in relation to neutral pictures. We also observed an increase in connection strength from the hippocampus to the amygdala, albeit at a smaller scale. These findings indicate that, during encoding, emotionally arousing information leads to a robust increase in effective connectivity from the amygdala to the hippocampus, regardless of its valence.
与中性事件相比，积极和消极情绪事件的记忆效果更好。对动物的研究表明，这种现象取决于杏仁核对海马体的影响。然而，在人类中，这两个脑结构如何在功能上相互作用，以及这些相互作用在积极和消极信息之间是否相似，在很大程度上尚不清楚。通过对586名健康受试者的功能磁共振成像（fMRI）数据进行动态因果建模，我们发现，与中性图片相比，在对积极和消极图片进行编码时，从杏仁核到海马体的连接强度迅速且显著增加。我们还观察到从海马体到杏仁核的连接强度也有所增加，尽管幅度较小。这些发现表明，在编码过程中，无论情绪唤起信息的效价如何，它都会导致从杏仁核到海马体的有效连接显著增强。
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