Bonifer Constanze, Cockerill Peter N
Institute of Cancer and Genomic Medicine, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK.
Trends Cancer. 2015 Nov;1(3):157-160. doi: 10.1016/j.trecan.2015.10.003. Epub 2015 Nov 5.
Cancer is primarily caused by mutations in genes encoding transcriptional regulators and signaling molecules. These mutations cooperate to deregulate the tight control over gene expression that is otherwise seen in normal cells. One consequence of this process is deregulated transcription factor (TF) activity. This forum article highlights novel strategies that use genome-wide chromatin structure profiling to identify the deregulated factors on which cancer cells depend, with the ultimate aim of targeting them.
癌症主要由编码转录调节因子和信号分子的基因突变引起。这些突变共同作用，解除了对基因表达的严格控制，而这种严格控制在正常细胞中是可见的。这一过程的一个后果是转录因子（TF）活性失控。这篇论坛文章重点介绍了一些新策略，这些策略利用全基因组染色质结构分析来识别癌细胞所依赖的失调因子，最终目标是针对这些因子进行靶向治疗。
