Liu Yong, Deisenroth Chad, Zhang Yanping
Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709, USA.
Trends Cancer. 2016 Apr;2(4):191-204. doi: 10.1016/j.trecan.2016.03.002. Epub 2016 Apr 4.
Ribosomal biogenesis is tightly associated with cellular activities, such as growth, proliferation, and cell cycle progression. Perturbations in ribosomal biogenesis can initiate so-called nucleolar stress. The process through which ribosomal proteins (RPs) transduce nucleolar stress signals via MDM2 to p53 has been described as a crucial tumor-suppression mechanism. In this review we focus on recent progress pertaining to the function and mechanism of RPs in association with the MDM2-p53 tumor-suppression network, and the potential implications this surveillance network has for cancer development.
核糖体生物合成与细胞活动紧密相关，如生长、增殖和细胞周期进程。核糖体生物合成的扰动可引发所谓的核仁应激。核糖体蛋白（RPs）通过MDM2将核仁应激信号转导至p53的过程已被描述为一种关键的肿瘤抑制机制。在本综述中，我们聚焦于核糖体蛋白在与MDM2-p53肿瘤抑制网络相关的功能和机制方面的最新进展，以及这个监测网络对癌症发展的潜在影响。
