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快速启动的科学——从抗逆转录病毒治疗开始的时机到方法

The science of rapid start-From the when to the how of antiretroviral initiation.

作者信息

Geng Elvin H, Havlir Diane V

机构信息

Division of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, California, United States of America.

出版信息

PLoS Med. 2017 Jul 25;14(7):e1002358. doi: 10.1371/journal.pmed.1002358. eCollection 2017 Jul.

DOI:10.1371/journal.pmed.1002358
PMID:28742819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5526524/
Abstract

In this Perspective linked to Koenig and colleagues, Elvin Geng and Diane Havlir discuss the next challenges for implementation research around rapid start antiretroviral treatment.

摘要

在这篇与凯尼格及其同事相关的观点文章中，埃尔文·耿和黛安·哈弗利尔探讨了围绕快速启动抗逆转录病毒治疗的实施研究面临的下一批挑战。

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本文引用的文献

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Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons living with HIV: A randomized unblinded trial.同日进行HIV检测并启动抗逆转录病毒治疗与HIV感染者的标准护理：一项随机非盲试验。
PLoS Med. 2017 Jul 25;14(7):e1002357. doi: 10.1371/journal.pmed.1002357. eCollection 2017 Jul.
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Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention.抗逆转录病毒疗法用于预防围产期HIV感染的益处与风险
N Engl J Med. 2016 Nov 3;375(18):1726-1737. doi: 10.1056/NEJMoa1511691.
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Effects of a multicomponent intervention to streamline initiation of antiretroviral therapy in Africa: a stepped-wedge cluster-randomised trial.多组分干预措施对简化非洲启动抗逆转录病毒治疗的效果：一项阶梯式楔形集群随机试验。
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Interventions to improve the rate or timing of initiation of antiretroviral therapy for HIV in sub-Saharan Africa: meta-analyses of effectiveness.撒哈拉以南非洲地区改善HIV抗逆转录病毒治疗启动率或启动时间的干预措施：有效性的荟萃分析
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HIV infection.HIV 感染。
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A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.在非洲开展的早期抗逆转录病毒治疗和异烟肼预防治疗试验。
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The PRECIS-2 tool: designing trials that are fit for purpose.PRECIS-2工具：设计符合目的的试验。
BMJ. 2015 May 8;350:h2147. doi: 10.1136/bmj.h2147.
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Retention in care under universal antiretroviral therapy for HIV-infected pregnant and breastfeeding women ('Option B+') in Malawi. Malawi 实施针对 HIV 感染孕妇和哺乳期妇女的普遍抗逆转录病毒治疗（“B+方案”）的患者保持治疗情况。
AIDS. 2014 Feb 20;28(4):589-598. doi: 10.1097/QAD.0000000000000143.
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Timing of antiretroviral therapy for HIV-1 infection and tuberculosis.抗逆转录病毒疗法治疗 HIV-1 感染和结核病的时机。
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Prevention of HIV-1 infection with early antiretroviral therapy.早期抗逆转录病毒疗法预防 HIV-1 感染。
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