Goes Ana Claudia Janiszewski, Reis Larissa Aparecida Busatto, Silva Marilia Barreto G, Kahlow Barbara Stadler, Skare Thelma L
Hospital Universitário Evangélico de Curitiba, Unidade de Reumatologia, Curitiba, PR, Brazil.
Hospital Universitário Evangélico de Curitiba, Unidade de Reumatologia, Curitiba, PR, Brazil.
Rev Bras Reumatol Engl Ed. 2017 Jul-Aug;57(4):294-298. doi: 10.1016/j.rbre.2016.07.011. Epub 2016 Aug 12.
Sleep disturbances are common in rheumatoid arthritis (RA) patients and contribute to loss of life quality.
To study associations of sleep quality with pain, depression and disease activity in RA.
This is a transversal observational study of 112 RA patients submitted to measurement of DAS-28, Epworth scale for daily sleepiness, index of sleep quality by Pittsburg index, risk of sleep apnea by the Berlin questionnaire and degree of depression by the CES-D (Center for Epidemiologic Studies Depression scale) questionnaire. We also collected epidemiological, clinical, serological and treatment data.
Only 18.5% of RA patients had sleep of good quality. In univariate analysis a bad sleep measured by Pittsburg index was associated with daily doses of prednisone (p=0.03), DAS-28 (p=0.01), CES-D (p=0.0005) and showed a tendency to be associated with Berlin sleep apnea questionnaire (p=0.06). In multivariate analysis only depression (p=0.008) and Berlin sleep apnea questionnaire (p=0.004) kept this association.
Most of RA patients do not have a good sleep quality. Depression and risk of sleep apnea are independently associated with sleep impairment.
睡眠障碍在类风湿关节炎（RA）患者中很常见，会导致生活质量下降。
研究RA患者睡眠质量与疼痛、抑郁及疾病活动度之间的关联。
这是一项对112例RA患者的横断面观察性研究，对患者进行了DAS-28测量、Epworth日间嗜睡量表、匹兹堡睡眠质量指数、柏林问卷评估睡眠呼吸暂停风险以及CES-D（流行病学研究中心抑郁量表）问卷评估抑郁程度。我们还收集了流行病学、临床、血清学和治疗数据。
只有18.5%的RA患者睡眠质量良好。在单因素分析中，匹兹堡指数测量的睡眠质量差与泼尼松每日剂量（p=0.03）、DAS-28（p=0.01）、CES-D（p=0.0005）相关，并且显示出与柏林睡眠呼吸暂停问卷相关的趋势（p=0.06）。在多因素分析中，只有抑郁（p=0.008）和柏林睡眠呼吸暂停问卷（p=0.004）保持这种关联。
大多数RA患者睡眠质量不佳。抑郁和睡眠呼吸暂停风险与睡眠障碍独立相关。
