Escuela Universitaria de Enfermería, Xerencia de Xestión Integrada de Ourense, SERGAS, Ourense, España.
Facultad de Ciencias de la Educación y del Deporte, Universidad de Vigo, Campus Pontevedra, España.
Med Clin (Barc). 2018 Mar 9;150(5):178-184. doi: 10.1016/j.medcli.2017.06.020. Epub 2017 Jul 22.
Randomised clinical trial performed in two urban health centres in Spain. To evaluate if educational intervention in women of perimenopausal age with hypertension, diabetes mellitus and/or dyslipidaemia could achieve significant changes in the reduction of biochemical and haemodynamic risk parameters.
The study included 320 women aged between 45 and 60 years old who were diagnosed with hypertension, diabetes mellitus and/or dyslipidaemia. They were randomly assigned to the experimental group (n=160) and the control group (n=160). The intervention group received three educational sessions and the control group received an informative leaflet sent by mail. Haemodynamic and biochemical variables were evaluated at baseline and one year later in both groups.
Women in the intervention group showed a decrease in low density lipoprotein (P=.034), (-5.89±29.8; 95% CI: -13.1/0.27) and an increase in high density lipoprotein (P=.013), (2.71±10.6; 95% CI: -1.36/6.20), as well as improvements in systolic blood pressure (P=.016), (-2.16±11.8; 95% CI: -4.4/0.01) and frequency (P=.003), (-1.46±10.3; 95% CI: -3.34/0.42) compared to women in the control group. Women in the control group significantly increased glucose (P=.04), (4.84±15.5; 95% CI: -0.75/31.3) and gamma-glutamyltranspeptidase (P=.031), (3.61±14.7; 95% CI: 0.87/6.36) levels more than those in the experimental group.
An educational intervention can be an effective method of reducing the parameters associated with an increased likelihood of cardiovascular disease in women at perimenopausal age with hypertension, diabetes mellitus and/or dyslipidaemia.
在西班牙的两家城市健康中心进行的随机临床试验。评估对处于围绝经期的高血压、糖尿病和/或血脂异常的女性进行教育干预，是否可以显著降低生化和血液动力学风险参数。
该研究纳入了 320 名年龄在 45 至 60 岁之间的女性，这些女性被诊断为高血压、糖尿病和/或血脂异常。她们被随机分为实验组（n=160）和对照组（n=160）。实验组接受了三次教育课程，对照组则收到了邮寄的信息传单。两组患者在基线和一年后均评估了血液动力学和生化变量。
实验组女性的低密度脂蛋白水平降低（P=.034），（-5.89±29.8；95%CI：-13.1/0.27），高密度脂蛋白水平升高（P=.013），（2.71±10.6；95%CI：-1.36/6.20），收缩压（P=.016）和频率（P=.003）也有所改善，分别为（-2.16±11.8；95%CI：-4.4/0.01）和（-1.46±10.3；95%CI：-3.34/0.42）。与对照组女性相比，实验组女性的血糖（P=.04）和γ-谷氨酰转移酶（P=.031）水平显著升高，分别为（4.84±15.5；95%CI：-0.75/31.3）和（3.61±14.7；95%CI：0.87/6.36）。
教育干预可能是一种有效的方法，可以降低围绝经期高血压、糖尿病和/或血脂异常女性心血管疾病风险增加的相关参数。
