Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Amsterdam Rheumatology and Clinical Immunology Center, Amsterdam, The Netherlands; Department of Rheumatology, Zuyderland Hospital, Heerlen, The Netherlands.
Clin Immunol. 2018 Jan;186:79-81. doi: 10.1016/j.clim.2017.07.022. Epub 2017 Jul 22.
Radiographs of hands and feet are traditionally the images that are used to assess structural damage progression in drug trials in patients with rheumatoid arthritis, aiming at proving the disease modifying capacity of a drug. Although treatment has largely improved over the past decade and consequently radiographic progression is limited in control arms in clinical trials, recent trials are still able to show inhibition of structural progression by new drugs. The requirements for the successful use of radiographic progression as an outcome in rheumatoid arthritis trials will be discussed in this paper.
手部和足部的 X 光片传统上被用于评估类风湿关节炎患者药物试验中的结构损伤进展，旨在证明药物的疾病修饰能力。尽管在过去十年中治疗已经有了很大的改善，因此临床试验中的对照组中放射学进展受到限制，但最近的试验仍然能够显示新药对结构进展的抑制作用。本文将讨论成功将放射学进展作为类风湿关节炎试验的结果的要求。
