Li Yan, Yao Xueping, Li Ying, Xu Feifei, Yang Zexiao
College of Animal Science and Technology, Sichuan Agricultural University, People's Republic of China.
College of Veterinary Medicine, Sichuan Agricultural University, People's Republic of China.
Microb Pathog. 2017 Sep;110:527-532. doi: 10.1016/j.micpath.2017.07.036. Epub 2017 Jul 22.
Rabbit haemorrhagic disease virus (RHDV) is a highly infectious pathogen that causes high mortality in wild and domestic rabbits. RHDV could be divided into two subtypes, classic RHDV and RHDVa, which present clear genetic, antigenic, and epidemiological differences. To further understand the nature of the diversity, we performed a genome-wide evolutionary study on the classic RHDV and RHDVa isolates. The results show that RHDV had experienced adaptive diversification with the dividing process of these subtypes. Furthermore, amino acid changes relevant to the adaptive diversification mainly cluster in viral capsid protein VP60. These results might be beneficial for a further understanding the function of VP60 and provide helpful hints for the genetic basis of RHDV emergence and re-emergence.
兔出血症病毒（RHDV）是一种高传染性病原体，可导致野生和家养兔子的高死亡率。RHDV可分为两个亚型，即经典RHDV和RHDVa，它们在遗传、抗原和流行病学方面存在明显差异。为了进一步了解这种多样性的本质，我们对经典RHDV和RHDVa分离株进行了全基因组进化研究。结果表明，RHDV在这些亚型的分化过程中经历了适应性多样化。此外，与适应性多样化相关的氨基酸变化主要集中在病毒衣壳蛋白VP60中。这些结果可能有助于进一步了解VP60的功能，并为RHDV出现和再次出现的遗传基础提供有益线索。
