Aaron Diamond AIDS Research Center, The Rockefeller University, New York, USA.
School of Public Health, City University of New York (CUNY), New York, USA.
AIDS Behav. 2018 Apr;22(4):1209-1216. doi: 10.1007/s10461-017-1871-x.
This study aimed to identify patients' physical and psychosocial experiences of an investigational long-acting injectable PrEP product to aid in the development of patient and provider education materials. Twenty-eight participants of a Phase 2 safety, tolerability, and acceptability study of long-acting integrase inhibitor cabotegravir (CAB-LA) were interviewed on their physical and psychosocial experiences of the injections. Five themes emerged through a framework analysis on these interview transcripts: (1) injection-related pain is highly variable across individuals; (2) pain is more impactful after the injections than during; (3) patient anxiety is critical, but does not determine the experience of injections and decreases over time; (4) intimacy and awkwardness of gluteal injections impacts patients' experiences; (5) patient education and care strategies can mitigate the above factors. These findings can inform further sociobehavioral research within Phase 3 efficacy trials of CAB-LA, as well as patient education and provider guidance for future injectable PrEP products.
本研究旨在确定患者对一种新的长效注射型 PrEP 产品的身体和心理社会体验，以帮助开发患者和提供者的教育材料。28 名参加长效整合酶抑制剂卡替拉韦（CAB-LA）的 2 期安全性、耐受性和可接受性研究的参与者接受了关于注射的身体和心理社会体验的访谈。通过对这些访谈记录的框架分析，出现了五个主题：（1）个体之间的注射相关疼痛差异很大；（2）注射后的疼痛比注射时更严重；（3）患者焦虑很重要，但并不能决定注射体验，且随时间推移而减轻；（4）臀部注射的亲密感和尴尬感会影响患者的体验；（5）患者教育和护理策略可以减轻上述因素的影响。这些发现可以为 CAB-LA 的 3 期疗效试验中的进一步社会行为研究以及未来注射型 PrEP 产品的患者教育和提供者指导提供信息。
