Gupta Bhumija, Acharya Aneesha, Pelekos Georgios, Gopalakrishnan Dharmarajan, Kolokythas Antonia
Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong.
Gerodontology. 2017 Dec;34(4):505-507. doi: 10.1111/ger.12287. Epub 2017 Jul 26.
Depression is a significantly prevalent health concern in geriatric populations. Selective serotonin reuptake inhibitor drugs (SSRI) are the most commonly prescribed antidepressant agents, with increasing rates of prescription. The present report aimed to present a concise review of the current understanding regarding SSRI effects on bone and dental implant outcomes.
A broad-based review and summary of literature pertaining to the effects of SSRI on bone metabolism and on dental implant survival was performed.
The available literature indicates that serotonin plays a significant role in bone metabolism and experimental reports demonstrate adverse impacts of SSRI on multiple pathways of bone metabolism. Early clinical reports suggest detrimental effects of SSRI on dental implant survival. The type of SSRI drug, dosage and host-related genetic and metabolic factors could be potential modulating factors. There is a paucity of data regarding SSRI usage and dental implant survival specific to geriatric cohorts.
As older individuals comprise a high-risk group for both high oral rehabilitation and SSRI use, clinicians should be aware the potential association between SSRI and dental implant failures. Well-designed investigations specific to geriatric cohorts are essential to understand the implications of SSRI use on dental implant prognosis.
抑郁症是老年人群中普遍存在的重大健康问题。选择性5-羟色胺再摄取抑制剂药物（SSRI）是最常用的抗抑郁药，其处方率不断上升。本报告旨在简要综述目前对SSRI对骨骼和牙种植体结果影响的认识。
对有关SSRI对骨代谢和牙种植体存活影响的文献进行广泛综述和总结。
现有文献表明，5-羟色胺在骨代谢中起重要作用，实验报告证明SSRI对骨代谢的多种途径有不利影响。早期临床报告提示SSRI对牙种植体存活有不良影响。SSRI药物的类型、剂量以及与宿主相关的遗传和代谢因素可能是潜在的调节因素。关于老年人群使用SSRI与牙种植体存活的相关数据匮乏。
由于老年人是口腔修复和使用SSRI的高危人群，临床医生应意识到SSRI与牙种植体失败之间的潜在关联。针对老年人群进行精心设计的调查对于了解使用SSRI对牙种植体预后的影响至关重要。
