Aljudaibi Suha Mohammed, Alqhtani Mohammad Abdullah Zayed, Tallab Mahmoud, Almeshari Ahmed A, Alqahtani Saeed M, Aldhuwayhi Sami, Alqahtani Nabeeh A
Department of Preventive Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Prosthetic Dental Science Department Faculty of Dentistry, Najran University, Najran, 66462, Kingdom of Saudi Arabia.
Sci Rep. 2025 Mar 15;15(1):8967. doi: 10.1038/s41598-025-92869-x.
The aim was to assess the clinical and radiographic peri-implant status among type-2 diabetic and non-diabetic individuals with major depressive disorders (MDD). Participants were divided into four groups; Group-1: patients with type-2 diabetes; Group-2: patients with MDD; Group-3: patients with type-2 diabetes and MDD; Group-4: healthy controls. Demographic data was collected, and medical history including most recent hemoglobin A1c (HbA1c) levels were retrieved from healthcare records. Peri-implant modified plaque and gingival indices (MPI and mGI) and peri-implant probing depth (PPD) were recorded; and crestal bone loss (CBL) was measured. Sample-size was estimated using data from a pilot investigation. Statistical analysis was performed using one way-analysis of variance and Bonferroni Post-hoc adjustment tests. P-vales below 0.05 were considered statistically significant. Thirty, 30, 30 and 30 individuals were included in groups 1, 2, 3 and 4. Mean HbA1c levels were higher in groups 1, 2 and 3 compared with Group-4 (P < 0.05). Thirty-seven, 40, 43 and 36 implants were present in groups 1, 2, 3 and 4, respectively. In groups 1, 2, 3 and 4, the implants were in function for a mean duration of 4.7 ± 2.4, 4.9 ± 1.8, 5.05 ± 1.7 and 10.6 ± 2.2 years, respectively. The mPI, mGI, PPD and CBL were significantly higher in groups 1, 2 and 3 than individuals in Group-4 (P < 0.05). There was significant correlation between peri-implant PD and HbA1c levels among individuals in Group-1 (P < 0.05). Peri-implant soft tissue and osseous statuses are compromised among patients with type-2 DM, and MDD regardless of whether these conditions occur individually or in combination. Clinical relevance: Peri-implant soft tissue and osseous statuses are compromised among patients with type-2 DM, and MDD regardless of whether these conditions occur individually or in combination.
目的是评估2型糖尿病患者和患有重度抑郁症（MDD）的非糖尿病个体的种植体周围临床和影像学状况。参与者被分为四组；第1组：2型糖尿病患者；第2组：MDD患者；第3组：2型糖尿病合并MDD患者；第4组：健康对照者。收集了人口统计学数据，并从医疗记录中获取了包括最近糖化血红蛋白（HbA1c）水平在内的病史。记录种植体周围改良菌斑和牙龈指数（MPI和mGI）以及种植体周围探诊深度（PPD）；并测量嵴顶骨吸收（CBL）。使用初步调查的数据估计样本量。采用单因素方差分析和Bonferroni事后检验进行统计分析。P值低于0.05被认为具有统计学意义。第1、2、3和4组分别纳入30、30、30和30名个体。与第4组相比，第1、2和3组的平均HbA1c水平更高（P < 0.05）。第1、2、3和4组分别有37、40、43和36颗种植体。在第1、2、3和4组中，种植体的平均使用时间分别为4.7±2.4、4.9±1.8、5.05±1.7和10.6±2.2年。第1、2和3组的mPI、mGI、PPD和CBL显著高于第4组个体（P < 0.05）。第1组个体的种植体周围PD与HbA1c水平之间存在显著相关性（P < 0.05）。无论2型糖尿病和MDD单独发生还是合并发生，其种植体周围软组织和骨组织状况均受到损害。临床意义：无论2型糖尿病和MDD单独发生还是合并发生，其种植体周围软组织和骨组织状况均受到损害。
