Kido H, Fukusen N, Ishidoh K, Katunuma N
Biochem Biophys Res Commun. 1986 Jul 16;138(1):275-82. doi: 10.1016/0006-291x(86)90276-7.
In adrenalectomized rats, diacylglycerol, a potent activator of protein kinase C, specifically enhanced the induction of tyrosine aminotransferase and ornithine decarboxylase by even maximally effective doses of dexamethasone phosphate, but itself had no effect on these enzyme inductions in the absence of glucocorticoid. The amplifications of enzyme induction by diacylglycerol was dose-dependent and the time courses of the amplified inductions were similar to those of the inductions by dexamethasone phosphate alone. Since diacylglycerol did not affect the induction of these enzymes by glucagon and insulin, its amplifying effect seemed to be specific for induction by glucocorticoids.
在肾上腺切除的大鼠中，二酰甘油作为蛋白激酶C的一种强效激活剂，即使使用最大有效剂量的磷酸地塞米松，也能特异性增强酪氨酸转氨酶和鸟氨酸脱羧酶的诱导作用，但在没有糖皮质激素的情况下，其本身对这些酶的诱导没有影响。二酰甘油对酶诱导的增强作用呈剂量依赖性，增强诱导的时间进程与单独使用磷酸地塞米松诱导的时间进程相似。由于二酰甘油不影响胰高血糖素和胰岛素对这些酶的诱导作用，其增强作用似乎对糖皮质激素的诱导具有特异性。
